Healthcare resource use and direct costs in severe aplastic anemia (SAA) patients before and after treatment with eltrombopag

Figures & data

Figure 1. Patient selection. ^aBaseline period: 1 month prior to the index date. ^bFollow-up period: 6 months after the index date. ^cThe first EPAG treatment during the identification period was deemed as index date.

Table 1. Baseline demographic and clinical characteristics.

	Overall (N = 82)
Age, yrs, mean (SD)	50.8 (20.6)
Sex, n (%)
Male	39 (47.6)
CCI at baseline, mean (SD)	1.1 (1.7)
Comorbidities, n (%)
Mild liver disease	8 (9.8)
Renal disease	5 (6.1)
Type 2 diabetes without chronic complications	4 (4.9)
Cerebrovascular disease	4 (4.9)
Congestive heart failure	2 (2.4)
Chronic pulmonary disease	2 (2.4)
Metastatic solid tumor	2 (2.4)
Type 2 diabetes with chronic complications	1 (1.2)
Rheumatic disease	1 (1.2)
Moderate to severe liver disease	1 (1.2)
US Region, n (%)
Northeast	11 (13.4)
North Central	16 (19.5)
South	38 (46.3)
West	17 (20.7)
Health insurance, n (%)
FFS	76 (92.7)
HMO and POS capitation	5 (6.1)
Other	1 (1.2)

Abbreviations. CCI, Charlson Comorbidity Index; FFS, fee for service; HCRU, healthcare resource utilization; HMO, health maintenance organization; n, total number within a subcategory; POS, point of service; SD, standard deviation; US, United States; yrs, years.

Figure 2. (A) Monthly all-cause HCRU in the baseline period and at month 6. (B) Monthly SAA-related HCRU in the baseline period and at month 6. Abbreviations. ER, emergency room; HCRU, healthcare resource utilization; SAA, severe aplastic anemia. ^aBaseline (1 month before EPAG initiation) monthly all-cause/SAA-related health care utilization. ^bMonth 6 after EPAG initiation monthly all-cause/SAA-related health care utilization in the follow-up period. ^cOutpatient visits were hospital setting or ambulatory surgical center, a skilled nursing facility, a residential substance abuse center, a comprehensive outpatient rehabilitation center, an end-stage-renal disease center or an outpatient Not Elsewhere Classified center.

Figure 3. Biweekly whole blood transfusions per patient for SAA patients treated with EPAG. Abbreviation. EPAG, eltrombopag. ^aAt Week 1, patients initiated EPAG treatment.

Figure 4. Monthly all-cause and SAA-related costs at 1 month before EPAG initiation and at month 6 following EPAG initiation. Abbreviations. SAA, severe aplastic anemia; ER, emergency room. ^aBaseline: 1 month before EPAG initiation. ^bFollow-up: month 6 after EPAG initiation. ^cOutpatient visits were hospital setting or ambulatory surgical center, a skilled nursing facility, a residential substance abuse center, a comprehensive outpatient rehabilitation center, an end-stage-renal disease center or an outpatient Not Elsewhere Classified center. ^dOther costs are expenses related to school, homeless shelters, assisted living facilities, group homes, mobile units, temporary lodging, health clinics, places of employment, military treatment facilities, custodial care facilities, adult living facilities, Federal qualified health centers, community mental health centers, intermediate care facilities, physical residential treatment centers, non-residential substance abuse centers, mass immunization centers, State or local public health centers, rural health clinics, independent laboratories, and other miscellaneous costs.