Cost effectiveness of benralizumab for severe, uncontrolled oral corticosteroid–dependent asthma in Sweden

Figures & data

Figure 1. Structure of the Model for Predicting Cost Effectiveness. Abbreviations. ED, emergency department; OCS, oral corticosteroids.

Table 1. Regular OCS Inputs in the Base Case Model.

Treatment	Value
Parameter
Benralizumab
Mean daily OCS dosage at baseline (mg)	14.73
Mean reduction in regular OCS dosage at Week 28 (%)	57.75
Responders at response assessment (Week 16) (%)	79.20
Nonresponders at response assessment (Week 16) (%)	20.80
Patients with complete OCS reduction at Week 28 (%)	62.90
SOC
Mean daily OCS dosage at baseline (mg)	14.73
Mean reduction in regular OCS dosage at Week 28 (%)	20.48
Patients with complete OCS reduction at Week 28 (%)	28.60

All data are from the ZONDA clinical trial.

Abbreviations. OCS, oral corticosteroids; SOC, standard of care.

Table 2. Results from Base Case Cost-effectiveness Analysis.

Outcome	Benralizumab	SOC plus OCS	Incremental value of benralizumab
Effectiveness
Life-years	20.67	20.56	0.11
QALYs	14.42	13.09	1.33
Costs (SEK)
Intervention costs	905,589	128,655	776,934
OCS costs	107,147	172,156	−65,008
Exacerbation costs	127,751	218,886	−91,135
Indirect costs	1,648,676	1,780,724	−132,049
Total	2,789,163	2,300,421	488,742
Cost-effectiveness (SEK)
Costs per life-year gained			4,604,288
Cost per QALY gained			366,855

Abbreviations. OCS, oral corticosteroids; QALY, quality-adjusted life-year; SEK, Swedish Kronor (2018); SOC, standard of care.

Figure 2. Cost-effectiveness Plane for Benralizumab vs. SOC Plus OCS from Probabilistic Sensitivity Analysis. Abbreviations. OCS, oral corticosteroids; QALY, quality-adjusted life-year; SEK, Swedish Kronor (2018); SOC, standard of care. Values shown indicate the uncertainty around the incremental cost-effectiveness ratio.

Figure 3. Cost-effectiveness Acceptability Curve for Benralizumab vs. SOC plus OCS. Abbreviations. OCS, oral corticosteroid; SEK, Swedish Kronor (2018); SOC, standard of care.

Figure 4. Parameters with the Greatest Impact on the ICER. Based on univariate sensitivity analysis. Abbreviations. AE, adverse event; ICER, incremental cost-effectiveness ratio; OCS, oral corticosteroids; SEK, Swedish Kronor (2018); SOC, standard of care.