The implications of suboptimal year-1 outcomes with disease-modifying therapy in employees with multiple sclerosis

Figures & data

Figure 1. Study population identified from the Workpartners Research Reference Database (RRDb).

Figure 2. Optimal and suboptimal year-1 outcomes among employees with MS treated with DMTs.

Table 1. Baseline demographic characteristics for employees with MS with and without suboptimal year-1 outcomes.

	Both cohorts (n = 488^a)		Without suboptimal year-1 outcomes (n = 241^b)		With suboptimal year-1 outcomes (n = 247^c)
Variable	Mean/%/$USD	SE	Mean/%/$USD	SE	Mean/%/$USD	SE
Employee age, years	43.22	0.45	43.87	0.61	42.60	0.66
Female	72.5%	2.0%	71.4%	2.9%	73.7%	2.8%
Marital status
Married	25.2%	2.0%	27.4%	2.9%	23.1%	2.7%
Not married	18.6%	1.8%	16.6%	2.4%	20.6%	2.6%
Missing marital status	56.1%	2.2%	56.0%	3.2%	56.3%	3.2%
Race
White	30.7%	2.1%	29.5%	2.9%	32.0%	3.0%
Black	5.5%	1.0%	5.8%	1.5%	5.3%	1.4%
Hispanic	5.1%	1.0%	6.6%	1.6%	3.6%	1.2%
Other race	0.2%	0.2%	0%	0%	0.4%	0.4%
Not specified	58.4%	2.2%	58.1%	3.2%	58.7%	3.1%
Annual salary	$65,242	$2,075	$68,737	$3,123	$61,898	$2,738
Full-time	79.7%	1.8%	79.3%	2.6%	80.2%	2.5%

Abbreviations. MS, multiple sclerosis; SE, standard error; USD, United States dollars.

^a All but annual salary (n = 405).

^b All but annual salary (n = 198).

^c All but annual salary (n = 207).

Table 2. Baseline clinical characteristics for employees with MS with and without suboptimal year-1 outcomes.

Variable	Both cohorts (n = 488)		Without suboptimal year-1 outcomes (n = 241)		With suboptimal year-1 outcomes (n = 247)
	Mean/%	SE	Mean/%	SE	Mean/%	SE
CCI	0.32	0.04	0.36	0.06	0.28	0.04
Comorbidities
Alcohol disorder	0.6%	0.4%	0.4%	0.4%	0.8%	0.6%
Anxiety	8.6%	1.3%	6.2%	1.6%	10.9%	2.0%
Arthritis	2.9%	0.8%	1.7%	0.8%	4.0%	1.3%
Depression	9.2%	1.3%	7.1%	1.7%	11.3%	2.0%
Diabetes	4.7%	1.0%	4.1%	1.3%	5.3%	1.4%
Hyperlipidemia	12.3%	1.5%	12.9%	2.2%	11.7%	2.1%
Hypertension	15.6%	1.6%	16.6%	2.4%	14.6%	2.2%
Thyroid disease	8.4%	1.3%	6.6%	1.6%	10.1%	1.9%
Chronic lung disease	3.5%	0.8%	4.6%	1.3%	2.4%	1.0%
Gastrointestinal disease	14.8%	1.6%	12.9%	2.2%	16.6%	2.4%
Tobacco use	2.9%	0.8%	2.5%	1.0%	3.2%	1.1%
MRI	58.4%	2.2%	58.9%	3.2%	57.9%	3.1%
Relapse	21.3%	1.9%	19.9%	2.6%	22.7%	2.7%

Abbreviations. CCI, Charlson Comorbidity Index; MRI, magnetic resonance imaging; MS, multiple sclerosis; SE, standard error.

Figure 3. Direct and indirect costs ($) for employees with and without suboptimal year-1 outcomes.

Data availability statement

The data utilized for this study were obtained through a license agreement with Workpartners.