The impact of omalizumab on paid and unpaid work productivity among severe Japanese cedar pollinosis (JCP) patients

Figures & data

Figure 1. Methodological Approach.

Figure 2. Definition of the Patient Population.

Table 1. Input Parameters of the Model.

Parameter	Base case value		Low value		High value		Source
Patient population
Prevalence*	38.80%		31.04%^#		46.56%^#		^4
	Severe	Most severe
Severity*	25.41%	29.01%					^19
Unsatisfied with treatment	27.50%	21.30%					^7
Seeking for care	43.80%	42.90%					^19
Specific IgE score ≥3	81.06%						^28
Symptoms´ period
Working days	15.00						^24
Activity days	21.00		10.00		43.00		^25^,^29
Reduction of impairment
Work impairment	13.61%		– 7.13%		– 20.09%		^12
Activity impairment	14.16%		– 8.42%		– 19.90%
Employment characteristics
	Male	Female	Male	Female	Male	Female
Employment rate*	88.81%	73.94%					^23
Daily working hours	9.03	8.47	8.63	8.10	9.37	8.78	^22^,^24
Average wage per hour in USD**	$ 22.98		$ 17.23^		$28.72^^		^22
Unpaid work
Unpaid working hours per day***	1.89	4.74					^25
Average specialist wage per hour****	$ 15.97		$ 15.44		$22.97		^22^,^30

Notes: *Reported rates depict the unweighted average across all ages. However, in the model, we implement the age-specific inputs listed in Tables A1–A3 the Supplementary Appendix. **We convert the values reported in JPY by the Japanese statistical office at the exchange rate of JPY = USD0.0095. ***We use the weekly average and determined the daily time spent on activities. ****We use the average wage of a cook (USD14.8), a nursing home care worker (USD16.4), a child care worker (USD17.2), and a home helper (USD15.4) as hourly wages to value the unpaid work activities with a specialist wage. ^#varied by ± 20.00%. ^varied by ± 25%.

Figure 3. Age- and gender-specific Distribution of Patients.

Figure 4. Avoided Hours lost attributable to paid and unpaid Work.

Figure 5. Avoided paid and unpaid Working Hours lost by Gender.

Figure 6. The Social Impact of Omalizumab.

Figure 7. Avoided Hours lost attributable to paid and unpaid Work per Patient.

Figure 8. Avoided Productivity Loss per Patient.

Figure 9. Deterministic Sensitivity Analysis.

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