The healthcare resource utilization and costs of chronic lung allograft dysfunction following lung transplantation in patients with commercial insurance in the United States

Figures & data

Figure 1. (A) Study design. This figure depicts the variable time following a patient’s lung transplantation and their index of CLAD, 12 months after the initial transplant. (B). Study design. This figure depicts the time before the first CLAD claim (pre-index) and the time following the first CLAD claim (post-index) in the time following lung transplantation.

Figure 2. Patient attrition, inclusion and exclusion criteria. This figure depicts the study inclusion and exclusion criteria that was applied to the initial sample, and the corresponding attrition at various criterium.

Table 1. Study Patient Demographic and Clinical Characteristics at Baseline (pre-transplant).

Patient characteristics	# of Patients/Mean	Pct of Patients/SD
Demographic Characteristics
Total # of Patients	129	100%
Female	45	35%
Age (Years), Mean ± SD	52	10.8
Age 18–40	18	14%
Age 41–64	111	86%
Clinical Characteristics
Charlson Comorbidity Index Score, Mean ± SD	2.1	1.4
Chronic Obstructive Pulmonary Disease (COPD)	21	16%
Pulmonary Fibrosis or Interstitial Lung Disease (ILD)	101	78%
Cystic Fibrosis (CF)	25	19%
Bronchiectasis	36	28%
Pulmonary Hypertension	38	29%
Pulmonary Arterial Hypertension	63	49%

Figure 3. Incidence of CLAD diagnosis relative to lung transplantation. This figure depicts the incidence of CLAD relative to lung transplantation. The horizontal axis depicts the months since lung transplant. The vertical axis depicts the number of incident diagnoses.

Table 2. Observable time for study patients.

	Total observed patient months	Mean patient months	SD	Min # of months	Max # of months	Median # of months
Pre-index	350	2.71	4.82	0^a	40	1
Post-index	3,895	30.19	24.05	3	115	22

^a0 means that patient didn't have claims in the pre-index period, their first claim started as the new Index BOS date. There were 29 patients with 0 months observed in the pre-index period

Figure 4. (A) Average number of inpatient admissions per patient per month. This figure depicts the average number of inpatient admissions per patient per month. The horizontal axis depicts the months since index diagnosis, negative values corresponding to the pre-period, and positive values corresponding to the post-period. The vertical axis depicts the mean inpatient admissions per patient per month. The solid area of the plot depicts inpatient admissions without ICU. The stripped area of the plot depicts inpatient admissions with ICU. (B) Average number of outpatient services per patient per month. This figure depicts the average number of outpatient services per patient per month. The horizontal axis depicts the months since index diagnosis, negative values corresponding to the pre-period, and positive values corresponding to the post-period. The vertical axis depicts the mean outpatient services per patient per month. (C) Average number of prescription fills per patient per month. This figure depicts the average number of prescription fills per patient per month. The horizontal axis depicts the months since index diagnosis, negative values corresponding to the pre-period, and positive values corresponding to the post-period. The vertical axis depicts the mean prescription fills per patient per month.

Table 3. Hospitalizations length of stay.

	# of Observations	Mean # of months	SD	Minimum # of months	Maximum # of months	Median # of months	IQR
Overall
Pre-index	24	6.96	6.79	2	24	4	5
Post-index	481	9.76	12.92	1	111	5	7
ICU
Pre-index	7	6.71	5.22	3	18	5	4
Post-index	175	13.71	17.31	1	111	7	11
Non-ICU
Pre-index	17	7.06	7.48	2	24	3	6
Post-index	306	7.5	8.82	1	86	5	5

Figure 5. Mean per patient per month direct medical costs overall. This figure depicts the mean direct medical costs per patient per month. The horizontal axis depicts the months since index diagnosis, negative values corresponding to the pre-period, and positive values corresponding to the post-period. The vertical axis depicts the mean per patient per month cost. The vertical line for each bar on the vertical axis depicts the standard deviation.

Figure 6. Mean per patient per month direct medical costs by category. This figure depicts the mean direct medical costs per patient per month by category. The horizontal axis depicts the months since index diagnosis, negative values corresponding to the pre-period, and positive values corresponding to the post-period. The vertical axis depicts the mean per patient per month cost. The plot has been stratified to correspond to the categories of outpatient services, pharmacy, inpatient admissions without ICU, and inpatient admissions with ICU.