Breast cancer-related mortality in Central and Eastern Europe: years of life lost and productivity costs

Figures & data

Table 1. Total number of deaths, YLL, YPLL, PVFLP and PVFLP/deaths by country in 2019.

Country	Number of deaths	YLL	YPLL	PVFLP (€)	PVFLP (€/BC-death)
Bulgaria	1,343	16,546	4,728	14,967,916	11,145
Croatia	770	10,760	2,154	12,650,059	16,429
Czech Republic	1,762	23,612	2,175	16,072,043	9,121
Hungary	2,200	27,534	6,926	38,813,087	17,642
Poland	7,037	101,288	15,507	85,062,587	12,088
Romania	3,441	46,516	8,826	45,736,741	13,292
Serbia	1,706	21,138	4,826	17,848,565	10,462
Slovakia	1,026	13,474	3,279	21,441,108	20,898
Slovenia	441	6,316	638	6,847,520	15,527
All countries	19,726	267,184	49,057	259,439,627	13,152^a

Abbreviations. YLL, Years of years of potential life lost; YPLL, Years of potential productive life lost; PVFLP, Present value of future lost productivity.

^aPlease note, this is the average PVFLP/breast cancer death for the four countries included in the analysis.

Table 2. Population size and crude mortality rates by country in 2019.

Country	Population size	Mortality rate
Bulgaria	6,975,761	0.0193%
Croatia	4,065,253	0.0189%
Czech Republic	10,671,870	0.0165%
Hungary	9,771,141	0.0225%
Poland	37,965,475	0.0185%
Romania	19,371,648	0.0178%
Serbia	6,945,235	0.0246%
Slovakia	5,454,147	0.0188%
Slovenia	2,088,385	0.0211%

Table 3. PVFLP results stratified by BC subtype.

BC molecular subtype	Estimated mortality ratio (%)	PVFLP (€)
HR+/HER2-	42.6	110,521,281
HR−/HER2-	22.5	58,373,916
HR+/HER2+	11.1	28,797,799
HR−/HER2+	7.0	18,160,774
Unknown	16.8	43,585,857
Total	100	259,439,627

Figure 1. Total present value of future lost productivity (PVFLP) in 2019. Abbreviations. PL, Poland; CZ, Czech Republic; SK, Slovakia; HU, Hungary; SLO, Slovenia; HR, Croatia; RO, Romania; RS, Serbia; BG, Bulgaria.

Figure 2. Deterministic sensitivity analysis (DSA) results for annual present value of future lost productivity PVFLP) per death varied using lower and higher input parameter values.

Table 4. PVFLP (€) results at the lower and upper values of the input parameters.

Parameter	PVFLP (€)/BC-death at lower value	PVFLP (€)/BC-death at upper value
Retirement age	7,484	23,100
Average earnings	11,837	14,467
Unemployment rate	11,837	14,467
Mortality	13,137	13,165
Life expectancy	13,152	13,152

Abbreviation. PVFLP, Present value of future lost productivity.

Table 5. PVFLP (€) results using minimum wage.

Country	Base case PVFLP (€)	Scenario analysis PVFLP (€)
Bulgaria	14,967,916	4,642,446
Croatia	12,650,059	4,372,098
Czech Republic	16,072,043	4,446,394
Hungary	38,813,087	12,986,512
Poland	85,062,587	33,766,099
Romania	45,736,741	10,146,440
Serbia	17,848,565	6,530,479
Slovakia	21,441,108	7,660,805
Slovenia	6,847,520	2,744,208
Total	259,439,627	87,295,480

Abbreviation. PVFLP, Present value of future lost productivity.