Figures & data
Figure 1. Model structure. Although not shown on the diagram, it is possible to recover from all disease states. Abbreviations. OM, otitis media; IPD, invasive pneumococcal disease; SoC, standard of care.
![Figure 1. Model structure. Although not shown on the diagram, it is possible to recover from all disease states. Abbreviations. OM, otitis media; IPD, invasive pneumococcal disease; SoC, standard of care.](/cms/asset/0ddd8979-0963-484c-8508-f4d6b22125bd/ijme_a_2339638_f0001_c.jpg)
Table 1. Results of the base-case analysis.
Figure 2. Results of the deterministic sensitivity analysis. (a) Cost results. Costs are displayed in billions. (b) QALY results. Abbreviations. DSA, deterministic sensitivity analysis; IPD, invasive pneumococcal disease; PCV20, 20-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life year; SOC, standard of care.
![Figure 2. Results of the deterministic sensitivity analysis. (a) Cost results. Costs are displayed in billions. (b) QALY results. Abbreviations. DSA, deterministic sensitivity analysis; IPD, invasive pneumococcal disease; PCV20, 20-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life year; SOC, standard of care.](/cms/asset/1ccd6b63-a6b0-4274-8c49-3a5b54abaee4/ijme_a_2339638_f0002_c.jpg)
Figure 3. Results of the probabilistic sensitivity analysis. Light yellow circles show the results of each iteration of the PSA; dark yellow diamond shows the mean of 1,000 iterations. Abbreviations. PCV20, 20-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life year.
![Figure 3. Results of the probabilistic sensitivity analysis. Light yellow circles show the results of each iteration of the PSA; dark yellow diamond shows the mean of 1,000 iterations. Abbreviations. PCV20, 20-valent pneumococcal conjugate vaccine; QALY, quality-adjusted life year.](/cms/asset/225575cc-8915-4989-8648-bf35986fe6cc/ijme_a_2339638_f0003_c.jpg)
Table 2. Scenario analysis: accrual of indirect effects with supplemental dose reduced by 25%.
Supplemental Material
Download MS Word (117.9 KB)Data availability statement
All data analyzed in this study are included within the article or Supplementary Material.