Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian patients

Abstract

Context: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.

Objective: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations.

Methods: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured.

Results: The major D allele was significantly associated with NAFLD patients (p = .002). DD genotype showed a significant increase in BMI and decrease in HDL-C. Also serum IL-1A was significantly correlated with the DD genotype. Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.

Conclusions: Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population.

Keywords:

• IL-1A insertion/deletion gene polymorphism
• non-alcoholic fatty liver disease

Acknowledgements

The authors would like to acknowledge Prof. Adel Ahmed Hassan (professor of tropical medicine, department of internal medicine, faculty of medicine, Suez Canal University) for his help in patient`s diagnosis.

Disclosure statement

None of the authors have any conflicts of interest.

Funding

No financial support was received.