Cardiopreventive effects of camel milk against carbon tetrachloride induced oxidative stress, biochemical and histological alterations in mice

Abstract

The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl₄) on the heart tissue of mice. Administration of a single dose of CCl₄ caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CCl₄ caused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities. Furthermore, CM ameliorated biochemical and histological parameters as compared to CCl₄-treated group. Overall, this study indicates that CM is efficient in inhibiting oxidative stress induced by CCl₄ and suggests that the administration of this milk may be helpful in the prevention of cardio-toxicity complications.

Keywords:

• CCl₄
• heart damage
• oxidative stress
• camel milk

Acknowledgements

This work was supported by the Laboratory of Animal Ecophysiology in the Faculty of Sciences of Sfax.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work has been funded by Ministry of Higher Education and Research, Scientific Research and Technology, Tunisia.