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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 126, 2020 - Issue 3
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Original Articles

High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats

, , , , , , , & show all
Pages 250-257 | Received 04 Jul 2018, Accepted 10 Aug 2018, Published online: 15 Oct 2018
 

Abstract

Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.

Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). After eight weeks of running, expression of miR-195 and myocardial function were evaluated.

Results: HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with CET. Our results showed that HIIT compared with CET increases left ventricular ejection fraction (LVEF%) and fractional shortening (FS%).

Conclusions: Our results indicated that exercise, especially HIIT is an appropriate strategy for reducing miR-195 and improving myocardial function in diabetic rats compared with CET.

Acknowledgements

This article was extracted from an MSc thesis.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The cost of this project has been funded by the research credit of the Paramedical School of Shahid Beheshti University of Medical Sciences. The authors thank Shahid Beheshti Deputy of Research Affairs for funding this project.

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