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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 128, 2022 - Issue 5
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Editorial

What the discovery of irisin receptor means to bone

Guobin Lia Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, PR China; View further author information
,
Na Caoa Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, PR China; View further author information
,
Peng Shangb Research & Development Institute in Shenzhen, Northwestern Polytechnical University, Shenzhen, PR ChinaORCID Iconhttps://orcid.org/0000-0001-5418-6240View further author information
ORCID Icon &
Huiyun Xua Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, PR China; Correspondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3037-0358View further author information
ORCID Icon
Pages 1137-1139 | Received 20 Feb 2020, Accepted 15 May 2020, Published online: 17 Jun 2020

Figures & data

Figure 1. Irisin, secreted abundantly by muscles during exercise, regulates bone resorption, and thermogenic gene program. Osteocytes and adipose cells express high level of αV/β5 integrins, a receptor of irisin. Irisin activation of αV/β5 in osteocytes promotes bone resorption by increasing RANKL and sclerostin expression. In addition, irisin-αV/β5 integrin signalling upregulates the expression of thermogenic genes (Ucp1 and Diol) in adipose tissues, which is responsible for fat expenditure.

Figure 1. Irisin, secreted abundantly by muscles during exercise, regulates bone resorption, and thermogenic gene program. Osteocytes and adipose cells express high level of αV/β5 integrins, a receptor of irisin. Irisin activation of αV/β5 in osteocytes promotes bone resorption by increasing RANKL and sclerostin expression. In addition, irisin-αV/β5 integrin signalling upregulates the expression of thermogenic genes (Ucp1 and Diol) in adipose tissues, which is responsible for fat expenditure.

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