Multiple novel functions of circular RNAs in diabetes mellitus

Abstract

Circular RNAs (circRNAs), as an emerging group of non-coding RNAs (ncRNAs), have received the attention given evidence indicating that these novel ncRNAs are implicated in various biological processes. Due to the absence of 5′ and 3′ ends in circ-RNAs, their two ends are covalently bonded together, and they are synthesised from pre-mRNAs in a process called back-splicing, which makes them more stable than linear RNAs. There is accumulating evidence showing that circRNAs play a critical role in the pathogenesis of diabetes mellitus (DM). Moreover, it has been indicated that dysregulation of circRNAs has made them promising diagnostic biomarkers for the detection of DM. Recently, increasing attention has been paid to investigate the mechanisms underlying the DM process. It has been demonstrated that there is a strong correlation between the expression of circRNAs and DM. Hence, our aim is to discuss the crosstalk between circRNAs and DM and its complications.

Keywords:

• Circular RNA (circRNA)
• diabetes
• insulin
• complications
• biomarker

Acknowledgements

The authors would like to thank Tehran University of Medical Sciences for kind supports.

Ethics approval and consent to participate: This article does not contain any studies with human participants or animals performed by any of the authors.

Consent for publication: All of the authors consent for publication.

Disclosure statement

The authors declare that there are no conflict of interests.

Data availability statement

The data used to support the findings of this study are included in the article.

Additional information

Notes on contributors

Sadra Samavarchi Tehrani

Sadra Samavarchi Tehrani prepared the writing and drafting; Golnaz Goodarzi prepared the writing and drafting; Ghodratollah Panahi collected the data; Mahmood Maniati completed the review and editing; Reza Meshkani supervised the data and approved the final manuscript.

Golnaz Goodarzi

Sadra Samavarchi Tehrani prepared the writing and drafting; Golnaz Goodarzi prepared the writing and drafting; Ghodratollah Panahi collected the data; Mahmood Maniati completed the review and editing; Reza Meshkani supervised the data and approved the final manuscript.

Ghodratollah Panahi

Sadra Samavarchi Tehrani prepared the writing and drafting; Golnaz Goodarzi prepared the writing and drafting; Ghodratollah Panahi collected the data; Mahmood Maniati completed the review and editing; Reza Meshkani supervised the data and approved the final manuscript.

Mahmood Maniati

Sadra Samavarchi Tehrani prepared the writing and drafting; Golnaz Goodarzi prepared the writing and drafting; Ghodratollah Panahi collected the data; Mahmood Maniati completed the review and editing; Reza Meshkani supervised the data and approved the final manuscript.

Reza Meshkani

Sadra Samavarchi Tehrani prepared the writing and drafting; Golnaz Goodarzi prepared the writing and drafting; Ghodratollah Panahi collected the data; Mahmood Maniati completed the review and editing; Reza Meshkani supervised the data and approved the final manuscript.