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Opinion Paper

Democratising the design and delivery of large-scale randomised, controlled clinical trials in primary care: A personal view

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Article: 2293702 | Received 25 Aug 2023, Accepted 04 Dec 2023, Published online: 05 Jan 2024

Figures & data

Figure 1. 27 March 2020: Chris butler at the Cynon Vale Medical practice.

Figure 1. 27 March 2020: Chris butler at the Cynon Vale Medical practice.

Figure 2. PANORAMIC recruitment from all four UK Devolved Administrations.

>120,000 screened 4509 practices referred potential participants to 65 GP practice Hubs accounting for >25% of recruitment: participants came from >6000 GP practices (each red dot represents a GP Practice)

Over 3000 randomised to nirmatrelvir/ritonavir vs usual care

>25,708 randomised to molnupiravir vs usual care

Figure 2. PANORAMIC recruitment from all four UK Devolved Administrations.>120,000 screened 4509 practices referred potential participants to 65 GP practice Hubs accounting for >25% of recruitment: participants came from >6000 GP practices (each red dot represents a GP Practice)Over 3000 randomised to nirmatrelvir/ritonavir vs usual care>25,708 randomised to molnupiravir vs usual care

Figure 3. PRINCIPLE trial of repurposed medicines: recruitment timelines.

Figure 3. PRINCIPLE trial of repurposed medicines: recruitment timelines.

Figure 4. Cumulative recruitment summary into PANORAMIC by 27 November 2023 (n = 28,534), trial ongoing.

Figure 4. Cumulative recruitment summary into PANORAMIC by 27 November 2023 (n = 28,534), trial ongoing.