Genetic factors for idiopathic choroidal neovascularization

ABSTRACT

Objective: The aim of this study was to investigate genetic factors associated with idiopathic choroidal neovascularization (ICNV).

Methods: We conducted a case-control study including 69 cases with ICNV and 114 controls who underwent cataract surgery. Single nucleotide polymorphisms (SNPs) from genes reported to be related to AMD, CNV and uveitis were selected for this study.

Results: In an univariate analysis, the rs669676 SNP located in the COL8A1 gene was associated with the proportion of people who has idiopathic CNV (${\mathrm{X}}^2$ = 9.3453, corrected p-value = 0.1). For the rs669676 SNP, minor allele homozygotes, in the dominant model of genotype analysis (GG versus AA-GA), it showed significant differences in the ICNV group vs controls (p = .01, OR = 1.219 (95%CI: 1.04–1.429)).

Conclusions: The rs669676 SNP located in the COL8A1 gene may contribute to a genetic susceptibility for ICNV.

KEYWORDS:

• Idiopathic choroidal neovascularization (ICNV)
• single nucleotide polymorphisms (SNPs)

Additional information

Funding

This study was supported by Funds of Clinical-Basic Cooperation of Capital Medical University (No. 15JL46), and the Priming Scientific Research Foundation for the senior researcher in Beijing Tongren Hospital, Capital Medical University (TRYY-KYJJ-2014-039), 2018 National Hai Ju Ren Cai Award.