Intraretinal hyperreflective foci in PXE-related retinopathy with acquired vitelliform lesions: a long-term follow-up

ABSTRACT

Purposes: To describe the long-term follow-up of a patient affected by Pseudoxanthoma Elasticum (PXE) and acquired macular vitelliform lesions in both eyes.

Material and methods: Case report

Results: We reported the 9-year follow-up of a patient affected by PXE. We described the onset and the resolution of the vitelliform macular lesions which lasted 5 years. The vitelliform lesion appeared almost simultaneously in both eyes with an initial increase in size, even though asymmetrical. We detected the intraretinal migration of hyper-reflective foci in both eyes during the follow-up. Choroidal neovascularization (CNV) occurred in her right eye during the follow-up. Visual acuity decreased from 20/20 to 20/32 in left eye; from 20/20 to 20/100 in her right eye.

Conclusions: we reported the natural history of acquired vitelliform lesion in PXE-related retinopathy describing the Intraretinal hyperreflective foci migration.

KEYWORDS:

• PXE
• pseudoxantoma elasticum
• acquired vitelliform lesion
• CNV
• hyper-reflective foci
• pigment migration

Acknowledgments

Authors gratefully acknowledge the collaboration of PXE Italia Onlus.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.