Association of variants in the ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) genes as risk factors for primary open-angle glaucoma development in a Brazilian cohort

Thiago Adalton Rosa Rodriguesa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, Brazil

https://orcid.org/0000-0001-9568-3323 View further author information

Bruno Batista de Souzaa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, BrazilView further author information

Victor de Haidar e Bertozzoa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, BrazilView further author information

Júlia Nicoliello Pereira de Castroa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, BrazilView further author information

Ana Carolina Lima Camargoa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, BrazilView further author information

Fernando Ferreira Costab Hematology and Hemotherapy Center, University of Campinas-UNICAMP, Campinas, BrazilView further author information

Rui Barroso Schimitic Glaucoma Service, Hoftalon Hospital, Londrina, Brazil;d Department of Ophthalmology, Faculty of Medical Sciences, PUC Paraná, Londrina, BrazilView further author information

Vital Paulino Costae Department of Ophthalmology, Faculty of Medical Sciences - University of Campinas - UNICAMP, Campinas, BrazilView further author information

José Paulo Cabral de Vasconcellose Department of Ophthalmology, Faculty of Medical Sciences - University of Campinas - UNICAMP, Campinas, Brazil

https://orcid.org/0000-0001-8220-6675 View further author information

Mônica Barbosa de Meloa Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG, University of Campinas - UNICAMP, Campinas, BrazilCorrespondence[email protected]

https://orcid.org/0000-0002-1801-5441 View further author information

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Association of variants in the ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) genes as risk factors for primary open-angle glaucoma development in a Brazilian cohort

Table 1. Primers used for amplification of the FOXC1 (rs2745572), TXNRD2 (rs35934224), and ATXN2 (rs7137828) variants.

Table 2. Descriptive analysis of allele and genotype frequencies between cases and controls.

Table 3. Association analysis of ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) SNVs between cases and controls through multivariate logistic regression, adjusted for age and gender.

Table 4. Association analysis of ATXN2 (rs7137828) SNV and clinical variables through linear regression.

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Association of variants in the ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) genes as risk factors for primary open-angle glaucoma development in a Brazilian cohort

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Table 1. Primers used for amplification of the FOXC1 (rs2745572), TXNRD2 (rs35934224), and ATXN2 (rs7137828) variants.

Table 2. Descriptive analysis of allele and genotype frequencies between cases and controls.

Table 3. Association analysis of ATXN2 (rs7137828), FOXC1 (rs2745572) and TXNRD2 (rs35934224) SNVs between cases and controls through multivariate logistic regression, adjusted for age and gender.

Table 4. Association analysis of ATXN2 (rs7137828) SNV and clinical variables through linear regression.

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