Risk- and protective factors for memory plasticity in aging

Figures & data

Table 1. Demographics of the participants. MMSE (Mini-Mental State Examination), CVLT (California Verbal Learning Test), MET (metabolic rate), IQ (intelligence quotient), BP Systolic (Systolic blood pressure), BP Diastolic (diastolic blood pressure), DHA (docosahexaenoic acid), BMI (body mass index)

	Young participants (29 female/22 male)		Old participants (53 female/32 male)		All participants across ages (82 female/54 male)
	Mean ± SD	Range	Mean ± SD	Range	Mean ± SD	Range
Age	26.32. ± 3.25	20.46 – .31.27	73.47. ± 2.97	69.03 – .82.09	55.79 ± 23.11	24.46–82.09
MMSE	29.18 ± 1.01	26 – 30	28.86 ± 1.18	26 – 30	28.98 ± 1.12	26 – 30
Education	15.52 ± 1.94	12.00 − 19.00	14.95 ± 2.87	7.50 − 21.00	15.17 ± 2.57	7.50 – 21
CVLT	15.35 ± 1.94	11 – 16	12.56 ± 3.00	4 – 16	11.87 ± 3.44	3 – 16
MET	3127.1 ± 3393.3	160.00–16,800.0	2839.6 ± 2440.8	198.0–16,308.0	2944.40 ± 2814.4	160.00–16,800.0
BP Systolic	120.40 ± 11.64	89 – 147	145.21 ± 19.626	105 – 194	135.91 ± 20.86	89 – 194
BP Diastolic	75.85 ± 8.97	56.0–103.5	81.365 ± 8.95	59.5–102.0	79.30 ± 9.32	56.0–103.5
Cholesterol	5.46 ± 0.78	4.11–7.69	5.98 ± 0.82	4.31–8.18	5.79 ± 0.85	4.11–8.18
DHA	1.87 ± 0.63	.94–3.57	2.24 ± 0.82	.94–3.57	2.11 ± 0.78	.94–5.39
IQ	112.51 ± 9.29	88.00–130.00	120.53 ± 10.41	91.00–144.00	117.52 ± 10.70	88.00–144.00
BMI	23.35 ± 3.86	18.5–36.0	25.19 ± 3.23	18.98–36.29	24.50 ± 3.58	18.15–36.29

Table 2. Demographics of the non-carriers and carriers of the APOE ɛ4 allele. MMSE (Mini-Mental State Examination), CVLT (California Verbal Learning Test), MET (metabolic rate), IQ (intelligence quotient), BP Systolic (Systolic blood pressure), BP Diastolic (diastolic blood pressure), DHA (docosahexaenoic acid), BMI (body mass index)

	Non-carriers (63 female/42 male)		Carriers (19 female/12 male)
	Mean ± SD	Range	Mean ± SD	Range
Age	55.95 ± 23.29	20.46–82.09	55.25 ± 22.84	22.20–77.35
MMSE	28.97 ± 1.13	26–30	29.00 ± 1.13	26–30
Education	15.09 ± 2.63	7.50–21	15.44 ± 2.37	8.00–19
CVLT	11.70 ± 3.47	3–16	12.42 ± 3.34	5–16
MET	2851.9 ± 2297.6	198.0–14,772.0	3271.73 ± 4208.6	160.0–16,800.0
BP systolic	136.03 ± 21.15	89 – 193	135.50 ± 20.17	98 – 194
BP diastolic	79.10 ± 8.62	56.0–102.0	79.98 ± 11.51	59.5–103.5
Cholesterol	5.77±	4.11–8.18	5.86 ± .85	4.47–7.97
DHA	2.15 ± .78	.94–5.39	1.96 ± .73	1.03–3.79
BMI	24.53 ± 3.61	18.15–36.29	24.40 ± 3.54	18.40–33.32

Figure 1. Change in memory performance in the two age groups. Individual change is illustrated as change in correct number of words recalled on the 100 words test from baseline to time point

Figure 2. Change in memory performance from baseline to time point 2 in the ɛ4 carriers and non-carriers