Figures & data
Figure 1. Compartmentation of paracetamol pharmacokinetics. The symbols have the following meaning: Sup. – suppository compartment, GIT – compartment of gastro-intestinal tract, Faeces – cumulative compartment of faeces, Liver – liver compartment for drug, Plasma – plasma compartment for drug, Urine – urine compartment for drug, Tissue – tissue compartment for drug, Liver (metabolite) – liver compartment for metabolite, Plasma (metabolite) – plasma compartment for metabolite, Tissue (metabolite) – tissue compartment for metabolite, Urine (metabolite) – urine compartment for metabolite, r(sup.) – non-linear drug release from suppository, kf – exchange rate from GIT to Faeces, m(liver) - saturable metabolism, kl, k-l – exchange rates between Liver and Plasma compartments for drug, e(plas.) – saturable elimination of drug, kd, k-d – exchange rates between Plasma and Tissue compartment for drug, kdm, k-dm – exchange rates between Plasma and Tissue compartment for metabolite, klm, k-lm – exchange rates between Liver and Plasma compartments for metabolite, em (plas.) – saturable elimination of metabolite.
Figure 2. Training and prediction of gripping-force. Thin line – simulation, thick line – measurements
