Study of Chlorophytum arundinaceum. Against Experimental Gastric Ulcer

Figures & data

Table 1.. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on ulcer index in ethanol-induced gastric ulcer model.

Groups	Ulcer index	%Protection
Control	1.53 ± 0.09	—
Alcohol extract (100 mg/kg)	0.31 ± 0.07	79.74%
Omeprazole (20 mg/kg)	0.58 ± 0.05	62.09%

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with the control group (ANOVA, followed by Tukey's multiple range test).

Table 2.. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on vascular permeability in rats.

Groups	Concentration of Evan's blue (µg/ml)
Control	8.20 ± 1.14
Alcohol extract (100 mg/kg)	2.03 ± 0.64

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with the control group (ANOVA, followed by Tukey's multiple range test).

Table 3. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on various acid secretary parameters against pylorus-ligated gastric ulcer model.

Parameters/groups	Control	Alcohol extract	Omeprazole
Ulcer index	0.79 ± 0.08	0.35 ± 0.04	0.18 ± 0.02
Volume of gastric secretion (ml/100 g b.w.)	1.64 ± 0.52	2.35 ± 0.38	2.70 ± 0.42
Total acidity (mEq/l)	7.25 ± 1.20	7.93 ± 1.40	2.49 ± 0.33
Total acid output (µEq/100 g b.w.)	9.80 ± 2.70	15.19 ± 3.73	6.14 ± 0.73
Pepsin activity (µg/ml)	94.17 ± 5.24	49.17 ± 5.45	60.50 ± 3.30

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with the control group (ANOVA, followed by Tukey's multiple range test).

Table 4.. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on various mucoprotective parameters against pylorus-ligated gastric ulcer model.

Parameters/groups	Control	Alcohol extract	Omeprazole
Total carbohydrates (mg/ml)	0.85 ± 0.13	0.85 ± 0.16	0.59 ± 0.10
Protein content (mg/ml)	1.64 ± 0.14	0.22 ± 0.05	0.84 ± 0.06
TC:PR ratio	0.55 ± 0.10	1.35 ± 0.21	0.72 ± 0.13

TC/PR, total carbohydrates/protein ratio.

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with control group (ANOVA, followed by Tukey's multiple range test).

Table 5.. Effect of 50% alcohal extract of Chlorophytum arundinaceum. on ulcer index and score for intensity in cold stress–induced gastric ulcer model.

Groups	Ulcer index	Score for intensity
Control	1.39 ± 0.19	2.67 ± 0.21
Alcohol extract (100 mg/kg)	0.50 ± 0.07	1.17 ± 0.17
Silymarin (100 mg/kg)	0.72 ± 0.09	1.50 ± 0.22

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with the control group (ANOVA, followed by Tukey's multiple range test).

Table 6.. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on MDA content, CAT level, and SOD level in CRS model.

Groups/parameters	MDA content	CAT level	SOD level
Normal	0.087 ± 0.004	0.0096 ± 0.0016	0.0352 ± 0.001
Stress control	0.120 ± 0.002**	0.0020 ± 0.0005**	0.0244 ± 0.002**
Alcohol extract (100 mg/kg)	0.046 ± 0.007	0.0124 ± 0.0011	0.0189 ± 0.001
Silymarin (100 mg/kg)	0.050 ± 0.003	0.0125 ± 0.0007	0.0452 ± 0.001

All values represent mean ± SEM; n = 6.

MDA, malondialdehyde; CAT, catalase; SOD, superoxide dismutase; CRS, cold restraint stress.

*p < 0.05 when compared with the stress control group (ANOVA, followed by Tukey's multiple range test).

**p < 0.05 when compared with the normal group.

Table 7.. Effect of 50% alcohol extract of Chlorophytum arundinaceum. on gastric emptying.

Groups	Concentration of phenol red (µg/ml)
Control	1.9 ± 0.208
50% alcohol extract (100 mg/kg)	5.23 ± 0.348
Omeprazole (20 mg/kg)	5.07 ± 0.318

All values represent mean ± SEM; n = 6.

*p < 0.05 when compared with control group (ANOVA, followed by Tukey's multiple range test).