Vasorelaxant Effect of Mexican Medicinal Plants on Isolated Rat Aorta

Figures & data

Table 1 Botanical and common names of plant species screened, their vouchers specimen names, parts employed, and traditional medicinal uses (Castillo & Monroy-Ortiz, 2000).

Plant name (Family)	Common name	Part used	Voucher number	Traditional uses
Brickellia cavallinesii. (Cass.) Gray (Cavanillessi)	Atanasia amarga, Gobernadora de Puebla, Hámula de Monterrey, Hierba del Becerro, Prodigiosa, Hierba Amargosa, Zacatechichi, Zacatexixi	Leaves, aerial parts	22031	Diabetes, stomachache, liver diseases, diarrhea, and cardiovascular diseases
Iresine calea. L. (Amaranthaceae)	Atlancuayo, Clacancuayo, Tlacancuayo, Tlancuayo	Leaves, stem, aerial parts	22026	Fever, rash, inflammation, hypertension, hepatitis
Laelia autumnalis. (Lex.) Lindley (Orchidaceae)	Flor de San Diego, Orquídea, Tzacxochitl	Flowers	22025	To avoid abortion
Lepechinia caulescens. (Ortega) Epling (Lamiaceae)	Betónica, Brenilla, Bretónica	Aerial parts, seeds, leaves	20386	Kidney diseases, diarrhea, vomit
Psyttacanthus calyculatus. (DC.) G. Don (Loranthaceae)	Cuaquetzpallagua, Injerto, Injerto de Huizache	Stem, leaves, roots	22027	Kidney diseases, hypertension, heart and nerves diseases, insomnia

Figure 1Effects of MeOH extracts from I. calea., P. calyculathus., B. cavallinesii., and L. caulescens. in aortic rings with (▪, E +) and without (○, E −) endothelium precontracted with NE 1 × 10^−7.5 M. (a) MeOH extract of I. calea.; (b) P. calyculathus.; (c) B. cavallinessi.; (d) L. autumnalis.. Results are expressed as the means ± SEM of six experiments. p < 0.05.

Table 2 Relaxatory effects induced by methanolic extracts from L. autumnaliss, B. cavallinesii, L. caulescens, P. calyculathus, and I. calea. on the contraction induced by NE in endothelium-intact and denuded aorta rings.

	With endothelium (+ E)		Without endothelium (− E)
Extract	IC50 (µg/ml)	Emax (%)	IC50 (µg/ml)	Emax (%)
Carbachol	0.009 ± 0.017	89.62 ± 3.66	N.A.	N.A.
L. autumnalis.	15.54 ± 1.94	84.58 ± 7.04	25.68 ± 7.92	54.68 ± 2.91
B. cavallinesii.	3.82 ± 0.29	98.16 ± 0.63	3.63 ± 0.57	99.96 ± 0.89
L. caulescens.	4.10 ± 0.52	90.17 ± 4.68	N.A.	N.A.
P. calyculathus.	N.A.	N.A.	N.A.	N.A.
I. calea.	N.A.	N.A.	N.A.	N.A.

N.A., No Active.

Figure 2Effects of MeOH extract of L. caulescens. on aortic rings with (•, E +) and without (○, E −) endothelium, (a) precontracted with NE (1 × 10^−7.5 M) and (b) precontracted with KCl (80 mM). Results are expressed as the mean ± SEM of six experiments. p < 0.05.

Figure 3Effects of IC₅₀ of methanolic extract of (a) L. caulescens. (4.10 µg/ml), (b) B. cavanillesii. (3.82 µg/ml), and (c) L. autumnalis. (15.54 µg/ml) on NE cumulative concentration-effect curve (1 × 10⁻¹¹ to 1 × 10⁻⁶ M) on rat aorta rings with endothelium. Each point represents the mean ± SEM of six aortic rings.

Figure 4Effects of MeOH extract of L. caulescens. in aortic rings with endothelium precontracted with NE 1 × 10^−7.5 M, (▪) in presence of L-NAME, inhibitor of NOS, and (○) indomethacin, inhibitor of COXs. Each point represents the mean ± SEM of six aortic rings.

Castillo EP, Monroy-Ortíz C (2000): Plantas Medicinales Utilizadas en el Estado de Morelos, Cuernavaca, Morelos, México, Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, pp. 26, 34, 55, 154, 173.

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