Chemical Composition and Antinociceptive Properties of Hyeronima alchorneoides. Leaves

Figures & data

Scheme 1 Molecular structures of compounds isolated from H. alchorneoides. leaves.

Figure 1Effect of the simiarenol (7.0, 14.1, and 23.4 µmol/kg, i.p.), isolated from the hexane fraction of H. alchorneoides. leaves, against acetic acid–induced pain in mice. Each column represents mean ± SEM of six experimental values. **p < 0.01.

Table 1 Comparison of antinociceptive effect of the extracts from H. alchorneoides. leaves with nonsteroidal anti-inflammatory and analgesic drugs given intraperitoneally to mice.

Tested material (10 mg/kg)	Writhing test (% inhibition)
MeOH extract	55.9 ± 3.7**
Hexane fraction	96.4 ± 1.0**
Ethyl acetate fraction	89.2 ± 2.2**
Dichloromethane fraction	82.7 ± 2.9**
Aspirin^a. (reference)	35.0 ± 1.4
Paracetamol^a. (reference)	38.0 ± 1.0

Each group represents the mean ± SEM of six experiments. p values * < 0.05 and ** < 0.01 compared with respective control value.

^a.Campos et al. (2002).

Figure 2Effect of simiarenol (10 mg/kg, i.p.), isolated from the hexane fraction obtained from H. alchorneoides. leaves, against formalin-induced pain in mice. Each column represents mean ± SEM of six experimental values. **p < 0.01.

Figure 3Effect of the simiarenol (10 mg/kg, i.p.), isolated from the hexane fraction obtained from H. alchorneoides. leaves, against capsaicin-induced pain in mice. Each column represents mean ± SEM of six experimental values. **p < 0.01.

Figure 4Effect of the simiarenol (10 mg/kg, i.p.), isolated from the hexane fraction obtained from H. alchorneoides. leaves, against glutamate-induced pain in mice. Each column represents mean ± SEM of six experimental values. **p < 0.01.

Campos F, Corrêa R, De Souza MM, Yunes RA, Nunes RJ, Cechinel-Filho V (2002): Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Drug Res 52: 455–461. [CSA]

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