619
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Bioassay-Guided Fractionation of Rubus suavissimus. Leaf Extracts Possessing NF-κ.B Inhibitory Activities and a Separable Cytotoxicity

, , , &
Pages 713-717 | Accepted 23 Aug 2005, Published online: 07 Oct 2008

Figures & data

Figure 1 Structure of rubusoside, one of the diterpenoids exhibiting sweet taste.

Figure 1 Structure of rubusoside, one of the diterpenoids exhibiting sweet taste.

Figure 2 Diagram depicting the extraction and fractionation procedures of R. suavissimus. leaf material.

Figure 2 Diagram depicting the extraction and fractionation procedures of R. suavissimus. leaf material.

Figure 3 Inhibition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C after 6 h of co-culture (n = 3).

Figure 3 Inhibition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C after 6 h of co-culture (n = 3).

Figure 4 Inhibition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C20 (n = 3).

Figure 4 Inhibition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C20 (n = 3).

Figure 5 Inhbition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C40 (n = 3).

Figure 5 Inhbition of LPS-induced NF-κ.B luciferase (Luc) activity by RUS-C40 (n = 3).

Figure 6 Chromatographic fingerprints of the active fraction RUS-C20 (a) and its three subfractions, RUS-C20A (b), RUS-C20B (c) with insets of UV spectra for two compounds (peak 1 and peak 2), and RUS-C20C (d) with insets of UV spectra of two distinct compound groups (group 1: peaks 3, 4, 5 and 6; group 2: peak 7).

Figure 6 Chromatographic fingerprints of the active fraction RUS-C20 (a) and its three subfractions, RUS-C20A (b), RUS-C20B (c) with insets of UV spectra for two compounds (peak 1 and peak 2), and RUS-C20C (d) with insets of UV spectra of two distinct compound groups (group 1: peaks 3, 4, 5 and 6; group 2: peak 7).

Figure 7 NF-κ.B inhibition by subfractions of RUS-C20 (µg/ml). Vertical lines on the top of bars represent one standard deviation of the mean value from triplicates.

Figure 7 NF-κ.B inhibition by subfractions of RUS-C20 (µg/ml). Vertical lines on the top of bars represent one standard deviation of the mean value from triplicates.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.