Involvement of Serotonin in the Antidepressant-like Effect of Extract from Kielmeyera coriacea. Stems

Figures & data

Figure 1 Diagram of coronal sections from − 7.3 to − 7.8 mm posterior to bregma through the rat brain, showing the microinjection sites in the DRN (indicated by dots) (Paxinos & Watson, 1986).

Figure 2 Mean (± SEM) of immobility time in the FST (A) and locomotor activity in the OFT (B) of HE from Kielmeyera coriacea. (Kc; 60.0 mg/kg), fluoxetine (FLUO; 10.0 mg/kg) or nortriptyline (NOR; 15.0 mg/kg) compared with control treated rats (C; 0.9% NaCl). All treatments were applied chronically by gavage. Dunnett's test revealed significant differences, *p < 0.05, (n = 7 to 10).

Figure 3 Mean ± SD of HE from Kielmeyera coriacea. on [³H]5-HT, [³H]NA, and [³H]DA uptake in rat brain cortex or striatum synaptosomes (three independent experiments, each performed in triplicate). Dunnett's test showed treatments effects *p < 0.05 and **p < 0.01 compared with the control group.

Figure 4 Mean (± SEM) of immobility time in FST for intra-DRN 5-HT (5.0, 10.0, and 20.0 nmol) (A) or 8-OHDPAT (0.3, 0.6, and 1.0 nmol) (B) compared with control group (C; intra-DRN vehicle-saline + 1% ascorbic acid) in chronically treated rats (gavage). Dunnett's test showed treatment effects *p < 0.05 compared with the control group (n = 7 to 10).

Figure 5 Mean (± SEM) of immobility time in the FST of intra-DRN vehicle (saline + 1% ascorbic acid), 5-HT (5.0 nmol), or 8-OHDPAT (0.6 or 1.0 nmol) in rats chronically treated (gavage) with saline or HE from Kielmeyera coriacea. (Kc; 60.0 mg/kg). Dunnett's test showed significant effects *p < 0.05 and **p < 0.01 compared with the control group (C, V + S, intra-DRN vehicle + saline by gavage) (n = 7 to 9).

Paxinos G, Watson C (1986): The Rat Brain In Stereotaxic Coordinates, Sidney, Academic Press.

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