Antinociceptive and Anti-inflammatory Activities of Viburnum lantana.

Figures & data

Table 1.. Results of V. lantana. on the acetic acid–induced writhing test in mice.

Treatment	Dose(mg/kg)	Abdominal stretching	% inhibition of stretching
Control (ISS)	0.2 mL	17.67 ± 1.67	—
Acetylsalicylic acid	300	9.83 ± 0.60^a.	44.37
V. lantana.	100	6.67 ± 3.22^a.	62.25
V. lantana.	200	1.83 ± 0.75^a.^b.	89.64

Values of abdominal stretching are mean ± SE, n = 6, p < 0.05 significant. Post hoc LSD (least significant difference test) test.

^a.p < 0.05, comparison with control group.

^b.p < 0.05, comparison with acetylsalicylic acid group.

Table 2.. Results of V. lantana., acetylsalicylic acid, morphine, and control groups on tail-flick test.

	Antinociceptive activity (%)
Groups	30th min	90th min	150th min
ISS (control)	2.03 ± 01.45	3.26 ± 04.26	1.21 ± 04.98
Acetylsalicylic acid (300 mg/kg)	22.74 ± 07.24	23.55 ± 08.87	37.29 ± 06.91^a.
Morphine (10 mg kg^−1)	46.31 ± 10.99^a.	69.38 ± 12.28^a.^b.	0.16 ± 06.61^b.
V. lantana. (100 mg/kg)	30.75 ± 16.05^a.	60.97 ± 21.61^a.^b.	40.43 ± 18.12^a.^c.

ISS, isotonic saline solution.

Values are mean ± SE, n = 6, p < 0.05 significant. Post hoc LSD (least significant difference test) test.

^a.p < 0.07 compared with control (ISS) group.

^b.p < 0.07 compared with acetylsalicylic acid group.

^c.p < 0.05 compared with morphine group.

Table 3.. Anti-inflammatory effect of V. lantana..

Groups	Dose	Paw edema(% mL)	Inhibition(%)
Control I (ISS)	0.1 mL	1.043 ± 0.084	—
Control II (ethyl alcohol)	0.1 mL	0.988 ± 0.075	—
Indomethacin	3 mg/kg	0.042 ± 0.015^a.^b.	95.70
V. lantana.	50 mg/kg	0.767 ± 0.108^c.	26.44
V. lantana.	100 mg/kg	0.559 ± 0.046^a.^b.^c.	46.39
V. lantana.	200 mg/kg	0.539 ± 0.076^a.^b.^c.	48.37

ISS, isotonic saline solution.

Values are mean ± SE, n = 6, p < 0.05 significant. Post-hoc Tukey's HSD test (Tukey's honestly significant difference test).

^a.p < 0.05 compared with control I (SF) group.

^b.p < 0.05 compared with control II (ethyl alcohol) group.

^c.p < 0.05 compared with indomethacin group.