Silymarin: An Effective Hepatoprotective Agent Against Diethylnitrosamine-Induced Hepatotoxicity in Rats

Figures & data

Table 1.. Effect of DEN and SIL on the status of AST, ALT, and ALP in serum of experimental animals.

Determination	Group I (Control)	Group II (DEN)	Group III (DEN + SIL)	Group IV (SIL)
AST (IU/L)	42.88 ± 1.82	83.52 ± 1.86a***	56.15 ± 7.47b***	43.66 ± 4.85
ALT (IU/L)	42.29 ± 1.29	124.44 ± 5.96a***	70.66 ± 9.13b***	44.65 ± 6.51
ALP (IU/L)	107.01 ± 1.23	211.03 ± 10.52a***	153.66 ± 5.83b***	119.15 ± 7.04

Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p < 0.001.

Table 2.. Effect of DEN and SIL on the status of γ-GT, LDH, and BIL in serum of experimental animals.

Determination	Group I (Control)	Group II (DEN)	Group III (DEN + SIL)	Group IV (SIL)
γ-GT (IU/L)	89.32 ± 3.64	201.73 ± 6.54a***	90.11 ± 4.74b***	90.28 ± 5.21
LDH (IU/L)	146.69 ± 2.04	336.07 ± 8.52a***	151.18 ± 0.59b***	147.29 ± 3.49
BIL (IU/L)	0.666 ± 0.08	1.92 ± 0.04a***	1.17 ± 0.06b***	0.61 ± 0.05

Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p < 0.001.

Figure 1 Figure 1 Effect of DEN and SIL on the status of AST, ALT, and ALP in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p<0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 2 Figure 2 Effect of DEN and SIL on the status of LDH γ-GT in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbols (***) and (**) represent statistical significance at p<0.001 and p<0.01, respectively.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 3 igure 3 Effect of DEN and SIL on lipid peroxidation in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p<0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 4 Effect of DEN and SIL on the activity of SOD in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p<0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 5 Figure 5Effect of DEN and SIL on the activity of CAT in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p<0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 6 Figure 6 Effect of DEN and SIL on the levels of vitamin C in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p<0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN+SIL);

, group IV (rats administered SIL alone)

Figure 7 Effect of DEN and SIL on the levels of vitamin E in liver tissue of experimental animals. Results are given as mean ± SE for six rats. Comparisons are made between: a, control rats (group I); b, DEN-treated rats (group II). The symbol (***) represents statistical significance at p < 0.001.

, group I (control rats administered vehicle alone);

, group II (rats administered a single dose of DEN alone);

, group III (rats administered DEN + SIL);

, group IV (rats administered SIL alone).