Effect of Citrullus colocynthis. on Hair Growth in Albino Rats

Figures & data

Table 1. Effect of Citrullus colocynthis. Schrad extracts on qualitative hair growth.

		Hair growth (days)
Sample no.	Treatment (topical)	Initiation time	Completion time
1.	Control (vehicle only)	12 ± 0.82	24 ± 1.02
2.	Standard (2% minoxidil solution)	6 ± 0.41***	20 ± 1.08***
3.	Petroleum ether extract (2% ointment)	5 ± 0.28***	18 ± 0.56***
4.	Petroleum ether extract (5% ointment)	4 ± 0.12***	18 ± 0.42***
5.	Ethanol extract (2% ointment)	11 ± 0.46	24 ± 1.34
6.	Ethanol extract (5% ointment)	10 ± 0.68*	24 ± 1.21

Values are mean ± SEM, n = 6.

*p < 0.05.

**p < 0.01.

***p < 0.001, significance versus control.

Figure 1 Qualitative effect of extracts of Citrullus colocynthis. Schrad on hair growth.

Table 2. Hair growth population (anagen/telogen ratio) after treatment with extracts of Citrullus colocynthis. Schrad.

	Percentage of hair follicles (%)
	After 10 days		After 20 days		After 30 days
Treatment^a.	Telogen	Anagen	Telogen	Anagen	Telogen	Anagen	T/A ratio
Control (vehicle)	58 ± 0.4	42 ± 0.4	55 ± 0.4	45 ± 0.4	53 ± 0.3	47 ± 0.3	1.21
Standard (2% minoxidil)	54 ± 0.3	46 ± 0.3	37 ± 0.9	62 ± 0.9	33 ± 0.5	67 ± 0.5*	0.49
2% pet. ether extract	52 ± 0.3	48 ± 0.3	37 ± 0.1	63 ± 0.1	28 ± 0.2	72 ± 0.2*	0.38
5% pet. ether extract	46 ± 0.4	54 ± 0.4	34 ± 0.2	66 ± 0.2	25 ± 0.2	75 ± 0.2*	0.33
2% ethanol extract	55 ± 0.5	45 ± 0.5	50 ± 0.6	50 ± 0.6	46 ± 0.8	54 ± 0.8	0.85
5% ethanol extract	54 ± 0.4	46 ± 0.5	46 ± 0.2	54 ± 0.2	43 ± 0.6	57 ± 0.6	0.75

Values are % mean ± SEM.

T/A, telogenic/anagenic ratio after 30 days of treatment.

^a.All extracts were applied topically.

*p < 0.05 (considered significant).

Figure 2 Percent frequency distribution of hair follicle population after 30 days of treatment with C. colocynthis..