Screening of Southeastern Brazilian Mikania. Species on Trypanosoma cruzi.

Figures & data

Table 1.. Mikania. species collected for in vitro. trypanocidal assay.

Species	Local	Voucher number	Extraction solvent	Crude extract
Mikania hoehnei. Robinson	Maringá-RJ	SPFR 04309	Hexane	M.h.H
			Ethyl acetate	M.h.Ea
			Ethanol	M.h.E
Mikania stipulacea. (M. Vahl) Willd	Maringá-RJ	SPFR 04123	Hexane	M.s.H
			Ethyl acetate	M.s.Ea
			Ethanol	M.s.E
Mikania cordifolia. (L. f.) Willd.	Campos de Jordão-SP	SPFR 05316	Dichloromethane methanol	M.c.D
			Methanol	M.c.M
Mikania camporum. B. Robinson	Campos de Jordão-SP	SPFR 7157	Dichloromethane	M.ca.D
			Methanol	M.ca.M
Mikania lasiandrae. DC.	Campos de Jordão-SP	SPFR 7158	Dichloromethane	M.l.D
			Methanol	M.I.M
Mikania micrantha. H. B. K.	Espírito Santo do Pinhal-SP	SPFR 7156	Dichloromethane	M.m.D
			Methanol	M.m.M

Table 2.. Trypanocidal activity of the crude extracts of Mikania. species.

Crude extract	Lysis %±SD^a.,b,c
M.h.H	51.57±9.8^ns
M.h.Ea	79.69±2.7**
M.h.E	70.32±8.2**
M.s.H	94.53±3.6**
M.s.Ea	57.03±4.9**
M.s.E	67.97±4.9**
M.c.D	66.25±5.9**
M.c.M	76.37±5.9**
M.ca.D	100**
M.ca.M	62.87±16.3**
M.l.D	96.63±2.93**
M.l.M	34.60±15.7^ns
M.m.D	94.10±1.5**
M.m.M	100**

See Table 1 for definition of extract abbreviations.

Significance was set at 1% (α = 0,01); *p < 0.01; **p < 0.001; ns, not significant.

^a.Percent reduction of the parasite number in mice infected blood±SD.

^b.Trypanocidal activity of the positive control was the 100%.

^c.The negative control did not show any reduction of the parasite numbers (the trypanocidal activity was 0).