Antiprotozoal Activity of Ethanol Extracts of Some Bomarea Species

Figures & data

Table 1  Evaluation of the antiprotozoal activity against promastigote forms of Leishmania spp. and the epimastigote form of Trypanosoma cruzi of fractions obtained from ethanol extracts of 13 species of Bomarea.

		Leishmania
Voucher	Fraction	PH8 (L. amazonensis) IC50 (μ g/mL)	M2903 (L. braziliensis) IC50 (μ g/mL)	PP75 (L. donovani) IC50 (μ g/mL)	Trypanosoma Epimastigote (Tulahuen) IC50 (μ g/mL)
Alzate 2897	B. bredemeyerana (Willd.) Mirb. (1)	23.4	45.0	90.0	71.3
	B. bredemeyerana (Willd.) Mirb. (2)	45.0	28.8	45.0	83.3
Alzate 2714	B. diffracta Baker (1)	20.8	30.6	50.0	> 100
	B. diffracta Baker (2)	19.8	10.2	24.9	79.2
Alzate 2951	B. edulis (Tussac) Herb. (1)	11.3	26.2	90.6	65.2
	B. edulis (Tussac) Herb. (2)	16.2	15.4	43.0	71.3
Alzate 2909	B. euryantha Alzate (1)	33.4	48.3	84.5	83.7
	B. euryantha Alzate (2)	17.3	6.2	96.5	67.2
Alzate 2923	B. glaberrima Pax (1)	35.8	35.8	48.7	65.2
	B. glaberrima Pax (2)	82.5	36.8	82.5	69.3
Alzate 2930	B. glaucescens (Kunth) Baker (1)	49.3	51.0	82.5	74.4
	B. glaucescens (Kunth) Baker (2)	28.7	36.8	96.5	71.3
Alzate 2890	B. hieronymi Pax (1)	42.9	47.0	98.6	83.7
	B. hieronymi Pax (2)	39.5	45.3	48.3	71.3
Alzate 2927	B. hirsuta (Kunt) Herb. (1)	96.5	90.6	96.6	71.3
	B. hirsuta (Kunth) Herb. (2)	32.6	41.2	41.2	75.0
Alzate 2931	B. linifolia (Kunth) Baker (1)	34.5	50.0	48.3	65.2
	B. linifolia (Kunth) Baker (2)	41.2	45.3	> 100	92.7
Alzate 2922	B. pardina Herb. (1)	37.5	41.2	36.8	73.2
	B. pardina Herb. (2)	90.0	73.6	80.6	76.8
Alzate 2810	B. patinii Baker (1)	32.3	27.1	81.9	77.5
	B. patinii Baker (2)	82.5	82.5	97.5	71.3
Alzate 2713	B. setacea (Ruiz & Pav.) Herb. (1)	29.3	5.4	5.3	65.2
	B. setacea (Ruiz & Pav. Herb. (2)	5.1	5.1	4.9	69.7
Alzate 2801	B. vestita Baker (1)	33.4	24.7	69.0	65.2
	B. vestita Baker (2)	49.3	37.5	97.5	83.7

Fractions were applied in concentrations of 10 to 100 μ g/mL. Highest antiprotozoal values are highlighted in bold font.Pentamidine IC₅₀ = 10 μ g/mL.Amphotericin B IC₅₀ = 0.2 μ g/mL.Benznidazole IC₅₀ = 2.0 μ g/mL.