Wound Healing Properties of Triterpenes from Buddleia scordioides in Diabetic Rats

Figures & data

Scheme 1  Structures of compounds 1 and 2.

Figure 1  Wound healing properties of compounds 1 and 2 and tensile strength of the wound in diabetic rats after 7 days. Values are mean + S.E. (n = 10 animals). *P < 0.05 and ** P < 0.01 as compared to vehicle (water) control. All wound area measurements were expressed as a percentage of the initial wound size.

Figure 2  Collagen content of saponins 1 and 2 treated and untreated wound granulation tissue from diabetic rats. Data are given as mean + S.E. for eight animals in each group. Statistically significant results are indicated as *P < 0.001 and **P < 0.01.

Figure 3  Hexosamine content of saponins 1 and 2 treated and untreated wound granulation tissue from diabetic rats. Data are given as mean + S.E. for eight animals in each group. Statistically significant results are indicated as *P < 0.001 and **P < 0.01.

Figure 4  Total protein content of saponins 1 and 2 treated and untreated wound granulation tissue from diabetic rats. Data are given as mean + S.E. for eight animals in each group. Statistically significant results are indicated as *P < 0.001 and **P < 0.01.

Figure 5  DNA content of saponins 1 and 2 treated and untreated wound granulation tissue from diabetic rats. Data are given as mean + S.E. for eight animals in each group. Statistically significant results are indicated as *P < 0.001 and **P < 0.01.

Table 1  Period of ephithelialization of saponins 1 and 2 treated wounds on diabetic rats.

	Number of days
Groups	1	2
Control	23 ± 3.7	23 ± 5.1
0.1	22 ± 3.6	21 ± 4.8
0.2	20 ± 2.9	19 ± 4.1
0.3	19 ± 2.1**	18 ± 2.6**
0.5	18 ± 1.9**	17 ± 1.9**

Values are mean ± S.E. (n = 6 animals). *p < 0.001 and **p 0.01 compared with vehicle control.