Immunomodulatory Activity of n-Butanol Extract of Oroxylum indicum

Figures & data

Table 1.  Effect of n-butanol fraction (100 mg/kg; p.o.) of Oroxylum indicum root bark on antibody formation in SRBC sensitized rats on stress-induced immunomodulatory activity.

Group	Antibody titer
Control	3.01 ± 0.34
n-Butanol	5.08 ± 0.49*

All values represent mean ± SEM, n = 6 in each group. *P < 0.05, when compared with control group (unpaired Student's t-test).

Table 2.  Effect of n-butanol fraction (100 mg/kg; p.o.) of Oroxylum indicum root bark on lipid peroxidation and antioxidant enzymes on stress-induced immunomodulatory activity.

Group	MDA content (μ mole/mg protein)	SOD (munits/mg protein)	CAT (units/min/mg protein)	GSH (μ mole/mg protein)
Stress-control	1.060 ± 0.082	0.046 ± 0.001	0.280 ± 0.039	0.014 ± 0.001
n-Butanol	0.650 ± 0.045*	0.068 ± 0.002*	0.623 ± 0.006*	0.043 ± 0.011*

All values represent mean ± SEM, n = 6 in each group. *P < 0.05, when compared with the control group (unpaired Student's t-test).

Table 3.  Effect of n-butanol fraction (100 mg/kg, p.o.) of Oroxylum indicum root bark on phagocytic activity as determined by carbon clearance method.

Group	Phagocytic index
Control	0.03 ± 0.01
n-Butanol	0.12 ± 0.03*

All values represent mean ± SEM, n = 6 in each group. *P < 0.05, when compared with control group (unpaired Student's t-test).

Table 4.  Effect of n-butanol fraction (100 mg/kg, p.o.) of Oroxylum indicum root bark on neutrophil adhesion.

Group	% NA
Control	24.22 ± 3.03
n-Butanol	46.20 ± 1.33*

All values represent mean ± SEM, n = 6 in each group. *P < 0.05, when compared with control group (unpaired Student's t-test).