Antihyperglycemic and hypoglycemic activities of Phyllanthus debilis aqueous plant extract in mice

Figures & data

Table 1.  Effects of oral administration of aqueous plant extract (APE) of P. debilis on fasting blood glucose level of normoglycemic mice.

Group	Pre-treatment	Post-treatment
		1 h	3 h	5 h
I	93.46 ± 1.28	95.63 ± 1.59	90.63 ± 1.47	89.16 ± 1.04
II	95.15 ± 2.34	92.55 ± 2.22	89.03 ± 3.54	91.46 ± 2.27
III	95.60 ± 1.13	97.10 ± 1.23	77.45 ± 1.49*	78.41 ± 1.61
IV	88.61 ± 1.49	80.59 ± 1.68	51.73 ± 0.91^**	68.47 ± 1.46^**
V	87.33 ± 0.87	49.89 ± 1.37^**	63.45 ± 1.77^**	75.37 ± 1.52^*

Each value represents mean ± SEM, n = 9.

I, Control (DW); II, 497.5 mg/kg APE; III, 995 mg/kg APE; IV, 1990 mg/kg APE; V, 33.5 mg/kg tolbutamide. *Compared to group I, p < 0.05. ** Compared to group I, p < 0.01.

Figure 1.  Effect of (A) high dose (1990 mg/kg) of aqueous plant extract of Phyllanthus debilis on glucose tolerance test after administration of 3 g/kg glucose solution, and (B) sucrose tolerance test after administration of 2 g/kg sucrose solution. Data represents mean ± SEM of 6 mice. ^**p < 0.01 compared with control.

Figure 2.  Effect of high dose (1990 mg/kg) of aqueous plant extract of Phyllanthus debilis on total red blood cell (RBC) counts of normoglycemic mice. Data represents mean ± SEM of 9 mice. *p < 0.05 compared with control.

Figure 3.  Effect of high dose (1990 mg/kg) of aqueous plant extract of Phyllanthus debilis on lipid profile of normoglycemic mice. Data represents mean ± SEM of 9 mice. **p <0.01 compared with control.