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Research Article

Anti-inflammatory and anti-nociceptive effects of Pterodon emarginatus stem bark alcohol extract

, , , , , , & show all
Pages 146-150 | Received 15 Dec 2007, Accepted 27 May 2008, Published online: 01 Feb 2009

Figures & data

Figure 1. Effect of the alcohol extract of Pterodon emarginatus stem bark (ExEtOH 1.0 g/kg, p.o. and s.c.) on the number of acetic acid-induced abdominal writhings. The vertical bars represent the means ± SEM. Indomethacin (20 mg/kg, s.c) was used as positive control. **p <0.01 and ***p <0.001.

Figure 1.  Effect of the alcohol extract of Pterodon emarginatus stem bark (ExEtOH 1.0 g/kg, p.o. and s.c.) on the number of acetic acid-induced abdominal writhings. The vertical bars represent the means ± SEM. Indomethacin (20 mg/kg, s.c) was used as positive control. **p <0.01 and ***p <0.001.

Figure 2. Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) in the tail flexion. Morphine was used as positive control. The points indicate the means ± SEM expressed in relative percentage to the zero time. p <0.05.

Figure 2.  Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) in the tail flexion. Morphine was used as positive control. The points indicate the means ± SEM expressed in relative percentage to the zero time. p <0.05.

Figure 3. Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) on total leukocyte migration. The vertical bars represent the means ± SEM. Dexamethasone (2 mg/kg s.c) was used as positive control. *p <0.05, **p <0.01 and ***p <0.001.

Figure 3.  Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) on total leukocyte migration. The vertical bars represent the means ± SEM. Dexamethasone (2 mg/kg s.c) was used as positive control. *p <0.05, **p <0.01 and ***p <0.001.

Figure 4. Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) on croton oil-induced ear edema in mice. The vertical bars indicate the means ± SEM of differences in weight between right and left ear plugs. Dexamethasone (2.0 mg/kg, s.c) was used as a positive control. *p <0.05 and ***p <0.001.

Figure 4.  Effect of the previous treatment with alcohol extract of Pterodon emarginatus stem bark (ExEtOH 0.1, 0.3, or 1.0 g/kg, s.c) on croton oil-induced ear edema in mice. The vertical bars indicate the means ± SEM of differences in weight between right and left ear plugs. Dexamethasone (2.0 mg/kg, s.c) was used as a positive control. *p <0.05 and ***p <0.001.

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