Evaluation of antidiabetic activity of the seeds of Swietenia macrophylla in diabetic rats

Figures & data

Table 1.  Effect of the methanol extract of seeds of Swietenia macrophylla on fasting plasma glucose level in normal rats.

Group	Dose	Blood glucose level mg/dl
		Day 1	Day 5	Day 9	Day 12
I (Normal)	-	75.83 ± 2.44	76.5 ± 2.60	76.00 ± 1.39	76.83 ± 1.91
II (Extract treated)	200 mg/kg (oral)	74.14 ± 2.65	71.67 ± 1.37 (3.33)	68.33 ± 1.65* (7.83)	66.00 ± 1.98** (10.98)
III (Extract treated)	300 mg/kg (oral)	75.5 ± 1.33	69.17 ± 1.17* (8.38)	64.17 ± 1.49** (15.01)	60.67 ± 1.76** (19.64)
IV (Glibenclamide)	10 mg/kg (oral)	77.33 ± 1.50	67.67 ± 1.91** (12.49)	63.50 ± 2.53** (17.88)	59.33 ± 1.54** (23.27)

Values are expressed as mean ± SEM from n = 6; * p < 0.05; and **p < 0.01 compared with normal group.

Table 2.  Effect of methanol extract of seeds of Swietenia macrophylla on oral glucose tolerance test (OGTT).

Group	Dose	Blood glucose level mg/dl
		0 h	1 h	2 h
I (Normal)	-	74.83 ± 2.93	96.83 ± 2.23	95.33 ± 2.70
II (Extract)	200 mg/kg (oral)	72.17 ± 2.61	93.00 ± 3.12	75.17 ± 2.30**
III (Extract)	300 mg/kg (oral)	68.33 ± 2.57	91.83 ± 3.21	72.00 ± 2.15**

Values are expressed as mean ± SEM from n = 6; **p < 0.01 compared with the normal group.

Table 3.  Effect of methanol extract of seeds of Swietenia macrophylla on fasting plasma glucose level in streptozotocin induced diabetic rats.

Group	Dose	Blood glucose level mg/dl
		Day 1	Day 5	Day 9	Day 12
I (Normal)	-	74.17 ± 1.12	73.17 ± 1.01	73.5 ± 1.04	74.33 ± 1.32
II (Diabetic control)	-	276.67 ± 3.41	283.00 ± 3.02	287.00 ± 2.68	289.67 ± 3.15
III (Diabetic + extract)	200 mg/kg (oral)	285.00 ± 3.68	236.83 ± 2.76** (16.90)	180.83 ± 3.73** (36.55)	146.83 ± 4.34** (48.48)
IV (Diabetic + extract)	300 mg/kg (oral)	295.67 ± 4.23	221.33 ± 7.89** (25.14)	162.83 ± 3.31** (44.92)	119.17 ± 2.81** (59.69)
V (Diabetic + glibenclamide)	10 mg/kg (oral)	297.00 ± 6.91	204.17 ± 6.01** (31.26)	141.83 ± 3.89** (52.24)	113.00 ± 2.77** (61.95)

Values are expressed as mean ± SEM from n = 6; **p < 0.01 compared with the diabetic control group.

Table 4.  Effect of methanol extract of seeds of Swietenia macrophylla on changes in body weight in streptozotocin induced diabetic rats.

Group	Dose	Initial body weight (g)	Final body weight (g)
I (Normal)	-	180.83 ± 3.96	189.17 ± 2.39
II (Diabetic control)	-	193.33 ± 7.71	167.50 ± 4.23
III (Diabetic + extract)	200 mg/kg (oral)	200.00 ± 9.40	192.50 ± 7.72
IV (Diabetic + extract)	300 mg/kg (oral)	189.17 ± 5.83	185.00 ± 5.32
V (Diabetic + glibenclamide)	10 mg/kg (oral)	201.67 ± 9.55	193.33 ± 8.43*

Values are expressed as mean ± SEM from n = 6; *p < 0.05 compared with the diabetic control group.

Table 5.  Effect of methanol extract of seeds of Swietenia macrophylla on serum lipid profiles and liver glycogen level in streptozotocin-induced diabetic rats.

Group	Dose	Cholesterol (mg/dl)	Triglycerides (mg/dl)	Liver glycogen (mg/g)
I (Normal)	-	63.67 ± 1.17	62.17 ± 1.40	21.97 ± 1.64
II (Diabetic control)	-	110.83 ± 3.27	99.67 ± 4.13	5.35 ± 0.53
III (Diabetic + extract)	200 mg/kg (oral)	62.17 ± 2.01**	70.50 ± 3.60**	11.63 ± 0.66**
IV (Diabetic + extract)	300 mg/kg (oral)	60.50 ± 2.31**	65.00 ± 3.16**	12.78 ± 0.68**
V (Diabetic + glibenclamide)	10 mg/kg (oral)	49.67 ± 2.85**	54.17 ± 2.63**	15.23 ± 0.49**

Values are expressed as mean ± SEM from n = 6; **p < 0.01 compared with the diabetic control group.