Effect of Persea macrantha against acute inflammation and adjuvant-induced arthritis in rats

Figures & data

Figure 1.  Anti-inflammatory activity of different extracts of Persea macrantha Nees. *p < 0.05 versus control.

Table 1.  Effect of various extracts of P. macrantha stem bark on primary lesions of adjuvant induced arthritis.

Group	Dose	Paw volume (mL)
		Day 1	Day 5	Day 21
Control	-	0.23 ± 0.01	0.42 ± 0.01	0.45 ± 0.01
Diclofenac	13.5 mg kg^−1	0.21 ± 0.01	0.32 ± 0.01* (23.83%)	0.39 ± 0.01 (13.33%)
PE	200 mg kg^−1	0.22 ± 0.01	0.29 ± 0.01* (30.95%)	0.31 ± 0.02* (31.11%)
CE	200 mg kg^−1	0.23 ± 0.01	0.38 ± 0.01(9.52%)	0.43 ± 0.01 (4.44%)
ME	200 mg kg^−1	0.21 ± 0.01	0.40 ± 0.01 (4.44%)	0.41 ± 0.02 (8.88%)
AE	200 mg kg^−1	0.22 ±  0.01	0.35 ± 0.02* (16.66%)	0.38 ± 0.02 (16.66%)

Values are expressed as mean ± SEM (n = 6).

*p < 0.05 versus control.

Figures in parentheses indicate the % inhibition.

Table 2.  Effect of various extracts of P. macrantha stem bark on secondary lesions of adjuvant induced arthritis in rats.

Group	Dose	Paw volume (mL)
		Day 1	Day 5	Day 21	Arthritic score
Control	–	0.23 ± 0.01	0.24 ± 0.01	0.35 ± 0.02	6.33 ± 0.21
Diclofenac	13.5 mg kg^−1	0.21 ± 0.01	0.22 ± 0.01 (23.83%)	0.26 ± 0.02 (25.71%)	5.66 ± 0.22
PE	200 mg kg^−1	0.21 ± 0.01	0.23 ± 0.01 (30.95%)	0.22 ± 0.01* (37.14%)	4.33 ± 0.33***
CE	200 mg kg^−1	0.23 ± 0.01	0.24 ± 0.01 (9.52%)	0.31 ± 0.01 (11.00%)	6.00 ± 0.25
ME	200 mg kg^−1	0.21 ± 0.01	0.24 ± 0.00 (4.44%)	0.33 ± 0.01 (5.71%)	6.16 ± 0.16
AE	200 mg kg^−1	0.21 ± 0.01	0.23 ± 0.01 (16.66%)	0.28 ± 0.01 (20.00%)	5.83 ± 0.30

Values are expressed as mean ± SEM (n = 6).

***p < 0.001 and *p < 0.05 versus control.

Figures in parentheses indicate the % inhibition.

Figure 2.  Anti-arthritic activity of Persea macrantha Nees. in adjuvant induced arthritic rats during different time periods (based on radiological scores). ***p < 0.001, **p < 0.01 and *p < 0.05 versus control.

Figure 3.  Radiographs of the adjuvant injected paw (Day 49). (A) Control, (B) PE-treated.