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Research Article

Effect of myricetin on behavioral paradigms of anxiety

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Pages 927-931 | Received 12 Jan 2008, Accepted 19 Jul 2008, Published online: 07 Aug 2009

Figures & data

Table 1. Effect of myricetin on time spent in open arms, entries in open and closed arms, and head dips in elevated plus maze.

Table 2. Effect of myricetin on m-CPP induced anxiety in elevated plus maze apparatus.

Figure 1. Effect of myricetin on time spent in lit zone and number of transitions in light/dark apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 1.  Effect of myricetin on time spent in lit zone and number of transitions in light/dark apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 2. Effect of myricetin on locomotion and rearing in open field apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 2.  Effect of myricetin on locomotion and rearing in open field apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 3. Effect of myricetin on number of head pokings in hole board apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 3.  Effect of myricetin on number of head pokings in hole board apparatus. Group 1 = control, group 2 = diazepam (1), group 3 = myricetin (10), group 4 = myricetin (30), group 5 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 4. Effect of myricetin on lithium sulfate (200 mg/kg) induced head twitches in rats. Group 1 = control, group 2 = myricetin (30), group 3 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 4.  Effect of myricetin on lithium sulfate (200 mg/kg) induced head twitches in rats. Group 1 = control, group 2 = myricetin (30), group 3 = myricetin (100) (n = 5). The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 5. Effect of myricetin (10 μg/mL) on cumulative concentration response curve (CCRC) of 5-HT using rat fundus. (n = 5). 1 = 3.77, 2 = 4.12, 3 = 4.41, 4 = 4.71, 5 = 5.01, 6 = 5.31. The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

Figure 5.  Effect of myricetin (10 μg/mL) on cumulative concentration response curve (CCRC) of 5-HT using rat fundus. (n = 5). 1 = 3.77, 2 = 4.12, 3 = 4.41, 4 = 4.71, 5 = 5.01, 6 = 5.31. The observations are mean ± SEM. *p < 0.05, as compared to vehicle (ANOVA followed by Dunnett’s test).

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