Protective effect of curcumin against myocardium injury in ischemia reperfusion rats

Figures & data

Table 1. Effect of curcumin on myocardium LVDP, LVEDP, +dp/dt_max and − dp/dt_min values.

Group	LVDP (mmHg)	LVEDP (mmHg)	+dp/dtmax (mmHg/s)	−dp/dtmin (mmHg/s)
1	98.36 ± 8.57	1727.43 ± 15.37	1802.35 ± 157.23	1326.05 ± 100.35
2	61.52 ± 5.92^b	1043.26 ± 98.56^b	1236.26 ± 118.36^b	862.59 ± 56.03^b
3	74.25 ± 6.94^d	1291.05 ± 113.03^d	1369.25 ± 105.73^d	969.32 ± 87.49^d
4	81.93 ± 8.33^d	1481.33 ± 122.49^d	1527.05 ± 144.29^d	1149.01 ± 94.26^d
5	92.49 ± 8.47^d	1622.13 ± 170.34^d	1783.26 ± 152.05^d	1315.26 ± 128.39^d

^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.

Table 2. Effect of curcumin on myocardium MDA levels.

Group	MDA
1	1.34 ± 0.12
2	5.39 ± 0.44^b
3	3.72 ± 0.41^d
4	2.42 ± 0.18^d
5	1.05 ± 0.11^d

^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.

Table 3. Effect of curcumin on myocardium SOD, CAT, GPx and GR activities.

Group	SOD	CAT	GPx	GR
1	153.85 ± 13.67	47.23 ± 3.79	67.39 ± 5.55	51.42 ± 4.93
2	48.38 ± 5.03^b	13.69 ± 1.72^b	23.29 ± 2.03^b	15.83 ± 1.33^b
3	94.14 ± 8.88^d	22.15 ± 2.61^d	44.37 ± 3.84^d	39.25 ± 3.55^d
4	132.5 ± 11.39^d	38.93 ± 3.06^d	52.92 ± 4.93^d	44.28 ± 4.15^d
5	144.57 ± 15.62^d	41.62 ± 3.77^d	61.36 ± 5.52^d	53.07 ± 4.91^d

^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.

Table 4. Effect of curcumin on myocardium LDH, CK-MB, Ca²⁺-ATPase and Na⁺-K⁺-ATPase activities.

Group	LDH (U/mg protein)	CK (U/mg protein)	Ca^2+-ATPase (μmol·mg protein^−1·h^−1)	Na^+-K^+-ATPase (μmol·mg protein^−1·h^−1)
1	1.48 ± 0.13	2.29 ± 0.25	1.65 ± 0.14	3.28 ± 0.25
2	6.28 ± 0.49^b	7.49 ± 0.61^b	0.59 ± 0.05^b	1.27 ± 0.14^b
3	4.02 ± 0.35^d	5.27 ± 0.48^d	0.87 ± 0.07^c	2.06 ± 0.19^d
4	3.16 ± 0.28^d	4.11 ± 0.37^d	1.21 ± 0.11^d	2.66 ± 0.23^d
5	2.69 ± 0.23^d	3.52 ± 0.31^d	1.41 ± 0.13^d	2.95 ± 0.25^d

^bp < 0.01, compared with group 1; ^cp < 0.05, ^dp < 0.01, compared with group 2.

Figure 1. Effect of curcumin on myocardium infarction size. ^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.

Figure 2. Effect of curcumin on myocardium Caspase-3, Bax and Bcl-2 protein expression. ^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.

Figure 3. Effect of curcumin on myocardium JAK2, p-JAK2, STAT3 and p-STAT3 protein expression. ^bp < 0.01, compared with group 1; ^dp < 0.01, compared with group 2.