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Research Article

Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide

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Pages 63-67 | Received 23 Sep 2015, Accepted 22 Aug 2016, Published online: 13 Sep 2016

Figures & data

Figure 1. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on mice for permanence time on the swivel bar in seconds. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. ***p < .001 versus control group (vehicle).

Figure 1. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on mice for permanence time on the swivel bar in seconds. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. ***p < .001 versus control group (vehicle).

Figure 2. Effect of OXL (50, 100 and 150 mg/kg; i.pon the number of writhes induced by acetic acid in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. ***p < .001 versus control group (vehicle).

Figure 2. Effect of OXL (50, 100 and 150 mg/kg; i.pon the number of writhes induced by acetic acid in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. ***p < .001 versus control group (vehicle).

Figure 3. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on paw-licking time in the first (A), and second (B) phases of the formalin test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet’s test. *p < .05; **p < .01; ***p <.001 versus the control group (vehicle).

Figure 3. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on paw-licking time in the first (A), and second (B) phases of the formalin test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet’s test. *p < .05; **p < .01; ***p <.001 versus the control group (vehicle).

Figure 4. Effect of OXL (50, 100 and 150 mg/kg; i.p.) on the duration of tonic convulsions in the Maximum Electroshock test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. **p < .01; ***p < .001 versus the control group (vehicle).

Figure 4. Effect of OXL (50, 100 and 150 mg/kg; i.p.) on the duration of tonic convulsions in the Maximum Electroshock test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. **p < .01; ***p < .001 versus the control group (vehicle).

Figure 5. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on the onset latency to the first seizure in the pentylenetetrazol induced seizures test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. **p < .01; ***p < .001 versus control group (vehicle).

Figure 5. Effect of OXL (50, 100 and 150 mg/kg, i.p.) on the onset latency to the first seizure in the pentylenetetrazol induced seizures test in mice. Values are expressed as mean ± S.E.M. ANOVA ‘one way’ followed by Dunnet's test. **p < .01; ***p < .001 versus control group (vehicle).