Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense

Figures & data

Table 1. Blood parameters of mice tested for Pleurotus sajor-caju toxicity.

Group	Pre-Rx WBC	Post-Rx WBC	Pre-Rx RBC (×10^6)	Post-Rx RBC (×10^6)	Pre-Rx PCV (%)	Post-Rx PCV (%)	Pre-Rx Hb (g/dl)	Post-Rx Hb (g/dl)
A1	8800	11,000	9.83	9.17	48	49	13.7	11.5
A2	10,500	8900	10.7	10.34	49	47	10.9	14.1
A3	8100	7900	8.79	9.11	49	51	15.1	16.1
A4	9700	10,000	9.96	11.11	47	48	15.7	16.3
B1	9800	9000	10.74	9.98	51	51	14.4	14.3
B2	7800	9100	11.13	10.64	49	48	10.7	14.2
B3	9500	9500	9.33	9.92	49	51	14.1	12.7
B4	9100	8700	10.1	10.2	46	47	15.8	16
C1	11,000	10,000	8.76	8.12	53	52	13.2	13.9
C2	8900	8600	9.93	9.96	46	50	12.4	13.1
C3	8700	9800	8.88	8.97	48	48	12.8	13.7
C4	9300	9000	9.23	9.56	45	45	14.9	15.2

Group A: control group, Group B: given 200 mg/kg of Pleurotus sajor-caju and Group C: given 400 mg/kg of Pleurotus sajor-caju. Rx = Treatment.

Figure 1. In vivo concentration-response curve of aqueous extract of Pleurotus sajor-caju against blood stream Trypanosoma congolense using global sigmoidal model of curve fitting.

Figure 2. Parasitaemia in mice infected with Trypanosoma congolense post-treatment with Pleurotus sajor-caju bark extract and diminazine aceturate with time (days after the first day of treatment).

Table 2. Treatment of Trypanosoma congolense with Pleurotus sajor-caju and diminazine aceturate.

Dose in mg/kg	Mean survival time (day) 6 SD	Cure rate (%)
0	3.17 ± 0.3	0
100	3.3 ± 0.2	0
150	4.17 ± 0.1	0
200	34.3 ± 0.03	50
250	>60	100
Diminazine aceturate (7 mg/kg)	>60	100

Figure 3. PCV and weight of mice pretreatment (day 9 post infection) and day 60 post treatments with Pleurotus sajor-caju extract and diminazine aceturate.

Figure 4. Blood differentials and white blood cell counts of experimental mice pretreatment (day 9 post-infection) and day 60 post-treatment with Pleurotus sajor-caju and diminazine aceturate.