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Research Article

Co-administration of walnut (Juglans regia) prevents systemic hypertension induced by long-term use of dexamethasone: a promising strategy for steroid consumers

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Pages 184-189 | Received 24 Oct 2015, Accepted 04 Sep 2016, Published online: 21 Sep 2016

Figures & data

Figure 1. Blood pressure in different animal groups. n = 6–8. Values are mean ± SEM. S: systolic pressure; D: diastolic pressure; MAP: mean arterial pressure; CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ▾p < 0.01 vs. W200 group, p < 0.05 vs. CTL and W100 groups, *p < 0.05 vs. DX group, and **p < 0.01 vs. DX group.

Figure 1. Blood pressure in different animal groups. n = 6–8. Values are mean ± SEM. S: systolic pressure; D: diastolic pressure; MAP: mean arterial pressure; CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ▾p < 0.01 vs. W200 group, †p < 0.05 vs. CTL and W100 groups, *p < 0.05 vs. DX group, and **p < 0.01 vs. DX group.

Figure 2. Heart rate in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone.

Figure 2. Heart rate in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone.

Figure 3. Glutathione peroxidase (GPX) of heart tissue in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ▾p < 0.01 vs. W200 group, †p < 0.05 vs. CTL and W100 groups, and *p < 0.05 vs. DX group.

Figure 3. Glutathione peroxidase (GPX) of heart tissue in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ▾p < 0.01 vs. W200 group, †p < 0.05 vs. CTL and W100 groups, and *p < 0.05 vs. DX group.

Figure 4. Malondialdehyde (MDA) of heart tissue in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ^p < 0.05 vs. CTL and W100 groups, $p < 0.05 vs. W200 group, *p < 0.05 vs. DX group, +p < 0.05 vs. W100 group, ‡p < 0.01 vs. DX, W100 + DX, and W200 + DX groups.

Figure 4. Malondialdehyde (MDA) of heart tissue in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. ^p < 0.05 vs. CTL and W100 groups, $p < 0.05 vs. W200 group, *p < 0.05 vs. DX group, +p < 0.05 vs. W100 group, ‡p < 0.01 vs. DX, W100 + DX, and W200 + DX groups.

Figure 5. MDA/GPX ratio in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. $p < 0.05 vs. CTL group, **p < 0.01 vs. DX group.

Figure 5. MDA/GPX ratio in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. $p < 0.05 vs. CTL group, **p < 0.01 vs. DX group.

Figure 6. Nitric oxide (NO) in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. $p < 0.05 vs. W200 group and *p < 0.05 vs. DX group.

Figure 6. Nitric oxide (NO) in different animal groups. n = 6–8. Values are mean ± SEM. CTL: control; W100: animal group which received 100 mg/kg/d of walnut extract; W200: animal group which received 200 mg/kg/d of walnut kernel extract; DX: animal group which received dexamethasone 0.03 mg/kg/d; W100 + DX: animal group which received 100 mg/kg/d walnut extract + dexamethasone; W200 + DX: animal group which received 200 mg/kg/d walnut extract + dexamethasone; Cap + DX: animal group which received 25 mg/kg/d captopril + dexamethasone. $p < 0.05 vs. W200 group and *p < 0.05 vs. DX group.