Medicinal plants and natural products in amelioration of arsenic toxicity: a short review

Figures & data

Table 1. Medicinal plants with arsenic toxicity ameliorative potential.

Sl. No.	Botanical name	Part/Constituents used	Experimental Model	Organ(s)/System/Cell line incolved	References
1	Withania somnifera	Root	Rats	Testes, liver, kidney	Kumar et al., 2015a,b
2	Ipomea aquatica	Aerial parts	Mice	Liver, kidney, heart, brain and testes	Dua et al., 2015
3	Mentha piperita	Leaf	Mice	Liver	Sharma et al., 2007
4	Carica papaya	Fruit	Mice	Testes	Singh & Kumari 2013
5	Phyllanthus emblica	Leaf	Mice	Liver, kidney and spleen	Sayed et al., 2015
6	Emblica officinalis	Fruit	Mice	Thymocytes	Singh et al., 2013
7	Pteris longifolia	Leaf	Rats	Liver, kidney	Kumar et al., 2015b
8	Triticum aestivum	Leaf	Rats	Liver, kidney	Lakshmi et al., 2015
9	Azadirachta indica	Leaf	Rats	Liver	Oyewole 2011
10	Tephrosia purpurea	Aerial parts	Rats	Liver	Baxla et al., 2014
11	Irvingia gabonensis	Leaf	Rats	Liver	Gbadegesin et al., 2014
12	Eupatorium buniifolium	Aerial parts	–	Renal Vero cells	Soria et al., 2008
13	Lantana grisebachii	Aerial parts	–	Renal Vero cells	Soria et al., 2008
14	Mandevilla pentlandiana	Aerial parts	–	Renal Vero cells	Soria et al., 2008
15	Sebastiania commersoniana	Aerial parts	–	Renal Vero cells	Soria et al., 2008
16	Heterothalamus alienus	Aerial parts	–	Renal Vero cells	Soria et al., 2008
17	Boerhavia diffusa	Aerial parts	–	H9c2 cardiomyocytes	Vineetha et al., 2013
18	Camellia sinensis	Black and green tea	Mice	Liver	Sinha et al., 2010
19	Camellia sinensis	Green tea	Rats	Liver	Acharyya et al., 2014
20	Camellia sinensis	Black and green tea	Rabbits	Haematological	Raihan et al., 2009
21	Camellia sinensis	Tannin-rich fraction of green tea	Rats	Liver and Kidney	Chandronitha et al., 2010
22	Malus domestica	Peel	–	H9c2 cardiac myoblast cells	Vineetha et al., 2014
23	Vitis vinifera	Seed proanthocyanidin extract	Mice	Testes	Li et al., 2015
24	Vitis vinifera	Seed	Rats	Liver	Xinjuan et al., 2011
25	Lantana grisebachii	Phyto-extract	–	Lymphocyte cells	Soria et al., 2014
26	Chlorophytum borivilianum	Root	Mice	Testes	Sharma & Kumar 2014
27	Terminalia arjuna	Whole plant	–	Chicken liver cell	Verma et al., 2007
28	Phyllanthus fraternus	Whole plant	–	Chicken liver cell	Verma et al., 2007
29	Trichosanthes dioica	Root	Rats	Liver, kidney, heart, brain	Bhattacharya & Haldar 2012a,b; 2013b
30	Trichosanthes dioica	Fruit	Rats	Liver, kidney, heart	Bhattacharya & Haldar 2012c, Bhattacharya et al., 2014
31	Moringa oleifera	Whole plant	–	Chicken liver cell	Verma et al., 2007
32	Moringa oleifera	Seed	Rats	Liver, Kidney	Gupta et al., 2005
33	Moringa oleifera	Leaf	Mice	Heart, Liver, Kidney	Sheikh et al., 2014
34	Corchorus olitorius	Leaves	Rats	Brain, Liver, Kidney, Heart	Das et al., 2010a, b, c
35	Psidium guajava	Leaves	Rats	Kidney, Haematological	Roy & Roy 2011; Tandan et al., 2012
36	Ocimum sanctum	Leaves	Rats	Liver, Kidney	Banu et al., 2009
37	Allium sativum	Bulb	Mice	Bone marrow	RoyChoudhury et al., 1996
38	Allium sativum	Bulb	Rats	Liver, Kidney, Ovary, Erythrocytes	Chowdhury et al., 2008; Adegboyega & Odunola 2012
39	Allium sativum	Bulb	–	Human malignant melanoma cells (A375), human keratinocyte cells (HaCaT), human normal dermal fibroblast cells	Chowdhury et al., 2008
40	Viscum album	Leaf	Rats	Erythrocytes	Adegboyega & Odunola 2012
41	Eichhornia crassipes	Root	Rats	Liver, spleen, kidney, lungs, skin	Quayum 2007
42	Zea mays	Fruit	Rats	Liver, kidney, heart, lungs, skin	Chowdhury et al., 2009
43	Spinacia oleracea	Aerial parts	Rats	Liver, spleen, kidney, lungs, skin	Umar 2007
44	Spirulina	Whole plant (algae)	Rats	Liver cells	Saha et al., 2005

Table 2. Natural products with arsenic toxicity ameliorative potential.

Sl. No.	Name	Experimental model	Organ(s)/System/Cell line involved	References
1	Rutin	Rats	Behavioural and general	Sárközi et al., 2015
2	β-Carotene	Mice	Liver, Kidney	Das et al., 2015
3	Leutin	Mice	Testes, liver	Niu et al., 2015; Li et al., (2016)
4	Diallyl trisulfide	Rats	Erythrocytes and lymphocytes	Prabu & Sumedha 2014
5	Silibinin	Rats	Kidney, Liver	Prabu & Muthumani 2012; Muthumani & Prabu 2012; 2013
6	Naringenin	Mice	Liver, Kidney	Roy et al., 2014
7	Naringenin	Rats	Liver, Kidney	Mershiba et al., 2013
8	Genistein	Rats	Heart	Fan et al., 2013
9	Ascorbic acid	Rats	Liver, Kidney, Haematogical	Singh & Rana 2007; Rana et al., 2010
10	Ascorbic acid	Mice	testes	Chang et al., 2007
11	α-Tocopherol	Mice	Liver, Kidney	Verma et al., 2004; Mittal & Flora 2007
12	Ascorbic acid + α-Tocopherol	Rats	Testes, Brain	Mukhopadhyay et al., 2013; Herrera et al., 2013; Kadirvel et al., 2007; Ramanathan et al., 2002, 2005.
13	Curcumin	Mice	Liver	Biswas et al., 2010; Gao et al., 2013
14	Curcumin	Rats	Liver, brain	Sankar et al., 2015; Yousef et al., 2008
15	Curcumin	–	Human Lymphocytes	Mukherjee et al., 2007
16	Quercetin	Rats	Liver, brain, testes	Ghosh et al., 2009; Jahan et al., 2015
17	Resveratrol	Cats	Liver, brain, lung	Zhang et al., 2014; Cheng et al., 2013, 2014
18	Resveratrol	Rats	Lung, Liver	Zhang et al., 2013a, b
19	Resveratrol	Mice	Heart	Zhao et al., 2008
20	All-trans retinoic acid	Rats	Uterus	Chatterjee & Chatterji 2011
21	Arjunolic acid	Mice	Liver, heart, brain, kidney, testes	Manna et al., 2007, 2008a, b; Sinha et al., 2008a, b

Table 3. Natural products with clinical arsenic toxicity ameliorative effects.

Sl. No.	Name	Material used (if applicable)	References
1	Vitamin A	–	Ahmad et al., 1998; Khandker et al., 2006
2	Vitamin C	–	Ahmad et al., 1998; Khandker et al., 2006; Melkonian et al., 2012
3	Vitamin E	–	Ahmad et al., 1998; Verret et al., 2005; Khandker et al., 2006; Melkonian et al., 2012
4	Spirulina	Whole plant (algae)	Sikder et al., 2000; Khan et al., 2001; Misbahuddin et al., 2006
5	Allium sativum	Oil from bulb	Misbahuddin et al., 2013
6	Nigella sativa	Oil from seed	Bashar et al., 2014

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