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Pharmaceutical Biology Volume 55, 2017 - Issue 1
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Research Article

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

Karpagam Veerappana Department of Biochemistry, VRR Institute of Biomedical Science (Affiliated to University of Madras), Chennai, Tamilnadu, India;
,
Sathishkumar Natarajanb Department of Horticulture, Sunchon National University, Suncheon, Republic of Korea;
,
Purushoth Ethirajc Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM University, Kattankulathur, Tamilnadu, India;
,
Umashankar Vetriveld Center for Bioinformatics, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamilnadu, India
&
Shila Samuela Department of Biochemistry, VRR Institute of Biomedical Science (Affiliated to University of Madras), Chennai, Tamilnadu, India; Correspondence[email protected]
Pages 368-373 | Received 29 Jan 2016, Accepted 23 Sep 2016, Published online: 08 Dec 2016

Figures & data

Figure 1. Chemical structure of celastrol and its analogues.

Figure 1. Chemical structure of celastrol and its analogues.

Figure 2. (A) Molecular interaction of IKKβ and celastrol. (B) Effect of celastrol (1 μM) on Aβ 1–42 (10 μM) induced cell death. (C) Effect of celastrol on Aβ 1–42 induced IKKβ activation.

Figure 2. (A) Molecular interaction of IKKβ and celastrol. (B) Effect of celastrol (1 μM) on Aβ 1–42 (10 μM) induced cell death. (C) Effect of celastrol on Aβ 1–42 induced IKKβ activation.
Supplemental material

Shila_Samuel_et_al_supplemental_content.zip

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