Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea

Figures & data

Figure 1. Chemical structures of 1–11 isolated from C. kilaea.

Table 1. Cytotoxic activity with normal and cancer cell lines of compounds isolated from C. kilaea (IC₅₀, μg/mL).

	Cell lines
Compounds	L-929	Hela	MCF-7	PC-3
Taraxasterol	-^a	–	–	–
Pectolinarigenin	–	–	35.53 ± 2.70	–
Dehydromelitensin	–	–	28.95 ± 0.95	25.00 ± 0.44
3′-O-Methyl eupatorin	–	–	–	–
Salvigenin	–	–	–	–
Cnicin	–	–	3.25 ± 0.03	31.53 ± 0.71
Apigenin	–	–	–	44.13 ± 0.33
Eupatorin	–	–	–	35.69 ± 0.30
Oleanolic acid	–	–	–	45.38 ± 0.42
Jaceosidin	–	–	–	–
Cirsimaritin	–	–	–	4.30 ± 1.55

^a IC₅₀>50 μg/mL, inactive.

Results are expressed as the mean ± SD.

Bold values are significantly different from other values (p < 0.05).