Aqueous extract of Securidaca longipendunculata Oliv. and Olax subscropioidea inhibits key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with Alzheimer’s disease in vitro

Figures & data

Figure 1. Total phenol content of aqueous extract of S. longipendunculata root and O. subscropioidea leaf. Values with different alphabet (a and b) are statistically different.

Figure 2. Total flavonoid content of aqueous extract of S. longipendunculata root and O. subscropioidea leaf. Values with different alphabet (a and b) are statistically different.

Figure 3. Ferric reducing antioxidant property of aqueous extract of S. longipendunculata root and O. subscropioidea leaf. Values with different alphabet (a and b) are statistically different.

Figure 4. ABTS^• scavenging ability of aqueous extract of S. longipendunculata root and O. subscropioidea leaf. Values with different alphabet (a and b) are statistically different.

Figure 5. Fe chelating ability of aqueous extract of S. longipendunculata root and O. subscropioidea leaf.

Figure 6. Fe²⁺-induced lipid peroxidation in rat’s brain by aqueous extract of S. longipendunculata root and O. subscropioidea leaf.

Table 1. IC₅₀ of Fe²⁺chelating ability, Fe²⁺-induced lipid peroxidation, acetylcholinesterase and butyrylcholinesterase inhibitory activities of the aqueous extracts of S. longipendunculata and O. subscropioidea .

	IC50 (mg/ml)
	S. longipendunculata	O. subscropioidea
Fe^2+chelation	105.57 ± 0.30	255.84 ± 0.15
Inhibition of Fe^2 +-induced  lipid peroxidation.	67.15 ± 0.35	111.03 ± 0.20
AChE	108.02 ± 0.15	110.35 ± 0.20
BChE	82.55 ± 0.13	108.44 ± 0.25

Figure 7. Acetylcholinesterase inhibition by aqueous extract of S. longipendunculata root and O. subscropioidea leaf.

Figure 8. Butylrycholinesterase inhibition by aqueous extract of S. longipendunculata root and O. subscropioidea leaf.