Lipid-lowering property of Clausena anisum-olens in hypercholesterolemic rats

Figures & data

Table 1. Mean serum cholesterol levels (mg/dL) of normal and hypercholesterolemic rats.

Treatment Groups	Baseline X ± SD	Post-induction X ± SD	Week 1 X ± SD	Week 2 X ± SD
Group A (Normal control)	66.53 ± 7.86	89.57 ± 5.44^a	94.60 ± 3.41^ab	90.36 ± 9.56^b
Group B (Negative control – NSS)	71.46 ± 1.72	168.14 ± 19.67^b	157.05 ± 2.61^c	141.09 ± 8.02^c
Group C (Positive control – Atorvastatin)	67.03 ± 5.51	159.05 ± 9.59^b	102.64 ± 8.81^b	80.90 ± 9.72^ab
Group D (200 mg/kg crude extract)	71.26 ± 7.57	183.73 ± 28.05^b	96.36 ± 1.83^b	87.21 ± 5.10^ab
Group E (400 mg/kg crude extract)	66.31 ± 4.19	162.39 ± 23.31^b	87.31 ± 3.67^a	74.72 ± 3.64^a

Data are presented as mean ± SD, n = 6 per group. The values in the same column with different superscripts letters are statistically significantly (p < 0.05).

Table 2. Mean serum HDL levels (mg/dL) of normal and hypercholesterolemic rats.

Treatment groups	Baseline X ± SD	Post-induction X ± SD	Week 1 X ± SD	Week 2 X ± SD
Group A (Normal control)	47.29 ± 2.01	47.96 ± 5.03^c	39.44 ± 5.52^a	41.46 ± 3.33^a
Group B (Negative control – NSS)	51.45 ± 1.70	43.01 ± 5.42^bc	39.50 ± 4.15^a	40.19 ± 3.20^ab
Group C (Positive control – Atorvastatin)	47.92 ± 3.05	38.53 ± 2.58^ab	45.42 ± 3.00^b	47.62 ± 2.08^bc
Group D (200 mg/kg crude extract)	47.89 ± 2.52	36.91 ± 4.63^ab	47.57 ± 5.17^b	47.77 ± 1.91^bc
Group E (400 mg/kg crude extract)	46.76 ± 4.35	32.97 ± 2.34^a	45.80 ± 5.20^b	52.09 ± 5.53^c

Data are presented as mean ± SD, n = 6 per group. The values in the same column with different superscripts letters are statistically significantly (p < 0.05).

Table 3. Mean serum triglyceride levels (mg/dL) of normal and hypercholesterolemic rats.

Treatment groups	Baseline X ± SD	Post-induction X ± SD	Week 1 X ± SD	Week 2 X ± SD
Group A (Normal control)	84.61 ± 7.75	88.00 ± 5.53^a	65.55 ± 4.85^a	56.67 ± 5.29^a
Group B (Negative control – NSS)	88.53 ± 6.58	147.41 ± 20.89^b	92.96 ± 13.49^b	89.63 ± 6.84^b
Group C (Positive control – Atorvastatin)	84.12 ± 15.62	155.31 ± 41.41^b	66.94 ± 14.84^a	55.94 ± 7.19^a
Group D (200 mg/kg crude extract)	75.13 ± 6.22	136.17 ± 37.04^ab	61.02 ± 9.75^a	58.09 ± 4.10^a
Group E (400 mg/kg crude extract)	89.29 ± 5.19	125.81 ± 37.45^ab	55.50 ± 5.89^a	52.79 ± 2.98^a

Data are presented as mean ± SD, n = 6 per group. The values in the same column with different superscripts letters are statistically significantly (p < 0.05).

Table 4. Mean serum LDL levels (mg/dL) of normal and hypercholesterolemic rats.

Treatment groups	Baseline X ± SD	Post-induction X ± SD	Week 1 X ± SD	Week 2 X ± SD
Group A (Normal control)	2.31 ± 8.46	24.01 ± 6.48^a	42.05 ± 7.22^b	37.57 ± 6.42^b
Group B (Negative control – NSS)	2.30 ± 3.83	95.65 ± 24.94^b	98.96 ± 3.87^c	82.97 ± 8.73^c
Group C (Positive control – Atorvastatin)	2.28 ± 3.74	89.46 ± 17.40^b	43.83 ± 9.28^b	22.09 ± 7.60^a^b
Group D (200 mg/kg crude extract)	8.35 ± 9.67	119.59 ± 18.28^b	36.59 ± 3.47^a^b	27.82 ± 4.11^b
Group E (400 mg/kg crude extract)	1.69 ± 7.97	104.27 ± 20.97^b	30.41 ± 5.85^a	12.06 ± 5.51^a

Data are presented as mean ± SD, n = 6 per group. The values in the same column with different superscripts letters are statistically significantly (p < 0.05).