Intracerebroventricular administration of the (1→6)-β-d-glucan (lasiodiplodan) in male rats prevents d-penicillamine-induced behavioral alterations and lipoperoxidation in the cortex

Figures & data

Table 1. Effects of d-penicillamine and lasiodiplodan on behavioral parameters.

	Groups
Parameters (s)	Ct	Las	d-Pen	Las + d-Pen
Time spent convulsing	0.0 ± 0.0	0.0 ± 0.0	280.0 ± 0.0^a	0.0 ± 0.0
Wet dog-shake	0.0 ± 0.0	0.0 ± 0.0	210.0 ± 94.0^a	50.0 ± 50.0
Rearing	570.0 ± 33.76^b	940.0 ± 50.60^a	280.0 ± 25.3	250.0 ± 18.44
Self-grooming	140.0 ± 25.3	150.0 ± 25.7	220.0 ± 40.0	170.0 ± 28.6
Tail extension	160.0 ± 36.8	260.0 ± 30.0	340.0 ± 42.9^c	150.0 ± 25.7

Data are expressed as mean ± S.E.M. Superscripts (a,b,c) represent statistical differences of p < 0.05, one-way ANOVA with post-hoc Bonferroni’s Multiple Comparison (n = 6) animals/group.

^a Significantly different from others groups.

^b Significantly different from the d-Pen and Las + d-Pen groups.

^c Significantly different from the Ct and Las + d-Pen groups.

Figure 1. Effects of D-penicillamine and lasiodiplodan on TBARS levels. Data are expressed as mean ± S.E.M. *Statistical difference between the D-Pen group and the other groups (p < 0.05); ^&Statistical difference between the Las + D-Pen group and Ct (p < 0.05) - (one-way ANOVA with post-hoc Bonferroni’s Multiple Comparison test, n = 6 animals/group).

Figure 2. Effects of D-penicillamine and lasiodiplodan on cerebral cortex histology of rats (100x). (a) cerebral cortex from the Ct group; (b) cerebral cortex from the Las group; (c) cerebral cortex from the D-Pen group; (d) cerebral cortex from Las + D-Pen group. Scale bar 25 μm.