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Short Communication

Identification of highly potent α-glucosidase inhibitory and antioxidant constituents from Zizyphus rugosa bark: enzyme kinetic and molecular docking studies with active metabolites

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Pages 1436-1441 | Received 13 Jul 2016, Accepted 02 Mar 2017, Published online: 21 Mar 2017

Figures & data

Table 1. α-Glucosidase inhibitory and antioxidant (DPPH) activities of fractions A-G.

Figure 1. Structures of isolated compounds (1-6) from active fractions D and G of Z. rugosa.

Figure 1. Structures of isolated compounds (1-6) from active fractions D and G of Z. rugosa.

Table 2. α-Glucosidase inhibitory and antioxidant (DPPH) activities of 1–6 and 2a–2l.

Scheme 1. Modified reactions of betunilic acid (2).

Scheme 1. Modified reactions of betunilic acid (2).

Figure 2. Comparison of molecular binding pose of compounds 1 (A) and 2 (B) in yeast α-glucosidase.

Figure 2. Comparison of molecular binding pose of compounds 1 (A) and 2 (B) in yeast α-glucosidase.
Supplemental material

Santi_Tip-Pyang_et_al_supplemental_content.zip

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