Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice

Keline Medeiros de Araújo-Vilgesa Laboratory of Cell Immunology, Faculty of Medicine, University of Brasilia Campus Darcy Ribeiro, Brasilia-DF, Brazil;

Stefan Vilges de Oliveirab Laboratory of Medical Parasitology and Vector Biology, Faculty of Medicine, University of Brasilia, Brasilia-DF, Brazil;

Shirley Claudino Pereira Coutoa Laboratory of Cell Immunology, Faculty of Medicine, University of Brasilia Campus Darcy Ribeiro, Brasilia-DF, Brazil;

Harold Hilarion Fokoued Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil;

Gustavo Adolfo Sierra Romeroc Laboratory of Leishmaniasis, Nucleo of Tropical Medicine, Faculty of Medicine, University of Brasilia, Campus Darcy Ribeiro, Brasilia-DF, Brazil;

Massuo Jorge Katod Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil;

Luiz Antonio Soares Romeiroe Laboratory of Development and Therapeutic Innovation, Nucleo of Tropical Medicine, Faculty of Medicine, University of Brasilia, Campus Darcy Ribeiro, Brasilia-DF, Brazil;

José Roberto Souza Almeida Leitef Laboratory of Morphology Faculty of Medicine, University of Brasilia Campus Darcy Ribeiro, Brasilia-DF, Brazil

Selma Aparecida Souza Kuckelhausa Laboratory of Cell Immunology, Faculty of Medicine, University of Brasilia Campus Darcy Ribeiro, Brasilia-DF, Brazil; ;f Laboratory of Morphology Faculty of Medicine, University of Brasilia Campus Darcy Ribeiro, Brasilia-DF, BrazilCorrespondence[email protected], [email protected]

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Figure 1. Percentage of MTT reduction by cultures of L. amazonensis (A) and peritoneal cells of Swiss mice (B) after 6 h of incubation, and inhibition of growth of P. falciparum after 48 (C₁) or 72 (C₂) h of incubation.

Table 1. Chemical structure of piplartine (1) and cinnamides (2–5), and concentrations able to inhibit 50% of the cells (IC₅₀), L. amazonensis, P. falciparum and peritoneal cells of Swiss mice.

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Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice

Table 1. Chemical structure of piplartine (1) and cinnamides (2–5), and concentrations able to inhibit 50% of the cells (IC₅₀), L. amazonensis, P. falciparum and peritoneal cells of Swiss mice.

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Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice

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Table 1. Chemical structure of piplartine (1) and cinnamides (2–5), and concentrations able to inhibit 50% of the cells (IC50), L. amazonensis, P. falciparum and peritoneal cells of Swiss mice.

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Table 1. Chemical structure of piplartine (1) and cinnamides (2–5), and concentrations able to inhibit 50% of the cells (IC₅₀), L. amazonensis, P. falciparum and peritoneal cells of Swiss mice.