The antitumour effects of eudesmin on lung cancer by inducing apoptosis via mitochondria-mediated pathway in the tumour cells

Li-Li Jianga Department of Acupuncture and Moxibustion, Linyi People's Hospital, Linyi, PR China;

Bai-Rong Sunb Department of Traditional Chinese Medicine, Linyi People's Hospital, Linyi, PR China;

Chao Zhengc Department of Orthopedic, Linyi People's Hospital, Linyi, PR China;

Gui-Lun Yangd Department of Medical Imaging, Linyi People's Hospital, Linyi, PR ChinaCorrespondence[email protected]

Figures & data

Figure 1. The antitumour effect of EDN on A549 cells.

Figure 2. Effects of EDN on the expression of P53, Bcl-2, Bax, caspase-9 and caspase-3 in A549 cells.

Figure 3. Effects of EDN on the expression of Akt and JNK in A549 cells.

Figure 4. Effects of JNK siRNA on expression of apoptosis-related proteins in A549 cells.

Figure 5. The effect of EDN on tumour weight and body weight of mice. **p < 0.01, compared with control group.

Figure 6. Effects of EDN on the expression of P53, Bcl-2, Bax, caspase-9, caspase-3 and JNK in A549 cells.