Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism

Figures & data

Figure 1. Pharmacokinetic profiles of asiatic acid in male Sprague-Dawley rats after oral administration of 20 mg/kg asiatic acid with or without glycyrrhizin (100 mg/kg/day for seven days) pretreatment. Each symbol with a bar represents the mean ± S.D. of six rats.

Table 1. Pharmacokinetic parameters of asiatic acid in rats after oral administration of asiatic acid (20 mg/kg; n = 6, mean ± S.D.) with or without treatment of glycyrrhizin.

Parameter	Control	Pretreatment of glycyrrhizin
Tmax (h)	0.54 ± 0.04	0.36 ± 0.02
Cmax (ng/mL)	324.67 ± 28.64	221.33 ± 21.06*
t1/2 (h)	2.04 ± 0.32	1.21 ± 0.27
AUC(0–inf) (μg h/L)	749.15 ± 163.95	496.12 ± 109.31*
Oral CL (L/h/kg)	27.59 ± 5.34	41.57 ± 9.19*

* p < 0.05 indicates significant differences from the control.

Figure 2. Effects of glycyrrhizin and/or verapamil on the efflux ratio of asiatic acid in the Caco-2 cell monolayer model. Each point represents the average ± S.D. of three determinations. *p < 0.05 indicates significant differences from the asiatic acid group.