Figures & data
Figure 1. Effects of curcumin (Cur) on gestational diabetes (GD) mice. On gestation day 10, both glucose (A) and insulin (B) tolerance were measured. On gestation day 20, fasting blood glucose (C) and insulin (D) levels were detected and hepatic glycogen content (E) was measured. Cur: curcumin; GD: gestational diabetes; GD + cur (L): GD mice administrated with cur (50 mg/kg); GD + cur (H): GD mice administrated with cur (100 mg/kg). *p < 0.05, compared with control; #p < 0.05, compared with GD.
Figure 2. Curcumin (Cur) alleviates oxidative stress on gestational diabetes (GD) mice. TBARS (A), GSH (B), SOD (C) and CAT (D) activities were assayed. GSH: glutathione; TBARS: thiobarbituric acid reactive substance; CAT: catalase; SOD: superoxide dismutase. *p < 0.05, compared with control; #p < 0.05, compared with GD.
Figure 3. Effects of curcumin (Cur) on AMPK signaling pathway in gestational diabetes (GD) mice. The expression levels of total AMPK, p-AMPK (A), pHDAC4, total HDAC4 (B) and G6Pase (C) were detected by Western Blot in the livers of pregnant mice on gestation day 20. (p)AMPK: (phosphor-) AMP-activated protein kinase; (p)HDAC4: (phosphor-) histone deacetylases; G6Pase: glucose-6-phosphatase. *p < 0.05, compared with control; #p < 0.05, compared with GD.
Figure 4. Curcumin (Cur) alleviates gestational diabetes (GD) reproductive outcome. Litter size (A) and body weight after birth (B) were recorded in different experimental groups (n = 12). *p < 0.05, compared with control; #p < 0.05, compared with GD.
Figure 5. Effects of curcumin (Cur) on glucose-6-phosphatase activity in gestational diabetes (GD) offspring. Glucose-6-phosphatase activity in the liver of offspring was measured at birth (n = 12). *p < 0.05, compared with control and GD + cur groups.
